Abstract
In order to find compounds possessing antibacterial activity, a number of new derivatives of N-(pyrimid-4-yl)ethylamine have been synthesized from 5-amino-4, 6-dichloropyrimidine, 2-amino-4, 6-dichloro-pyrimidine, 4, 6-dichloro-2-phenylpyrimidine, and 2,4-dichloro-6-methylpyrimidine and various ethylamines substituted in the β-position. Several derivatives of 4-(4′-methylpiperazinyl)pyrimidine have also been obtained. Results of a biological study of the compounds obtained are presented.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
V. N. Sokolova and O. Yu. Magidson, KhGS [Chemistry of Heterocyclic Compounds], 4, 343, 1968.
V. N. Sokolova and O. Yu. Magidson, KhGS [Chemistry of Heterocyclic Compounds], 3, 519, 1968.
R. Hull, J. Chem. Soc., 2214, 1951.
R. K. Robins, K. L. Dille, and B. E. Christensen, J. Org. Chem., 19, 930, 1954.
S. Gabriel and J. Colman, Ber., 32, 1533, 1899.
J. R. Marshall and J. Walker, J. Chem. Soc., 1004, 1951.
J. A. Hendry and R. F. Homer, J. Chem. Soc., 328, 1952.
E. Butther, Ber., 36, 2227, 1903.
M. Langerman and C. K. Banks, J. Am. Chem. Soc., 73, 3011, 1951.
D. J. Brown, The Pyrimidines, 1962.
Author information
Authors and Affiliations
Additional information
For part II, see ¦1¦.
Rights and permissions
About this article
Cite this article
Sokolova, V.N., Modnikova, G.A., Magidson, O.Y. et al. Derivatives of n-(pyrimid-4-yl)ethylamine. Chem Heterocycl Compd 6, 392–397 (1970). https://doi.org/10.1007/BF00471251
Issue Date:
DOI: https://doi.org/10.1007/BF00471251