Chemistry of Heterocyclic Compounds

, Volume 15, Issue 1, pp 63–65 | Cite as

Synthesis of isotryptamines and tetrahydro-γ-carbolines from 2-indolylacetic acid derivatives

  • F. A. Trofimov
  • V. I. Garnova
  • A. N. Grinev
  • N. G. Tsyshkova
Article

Abstract

The reaction of ethyl 2-indolylacetate with alkylamines gave the corresponding amides, which were reduced with sodium borohydride to isotryptamines. The latter were converted to 1,2,3,4-tetrahydro-γ-carboline derivatives by condensation with formaldehyde.

Keywords

Sodium Formaldehyde Ethyl Organic Chemistry Amide 

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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • F. A. Trofimov
    • 1
    • 2
  • V. I. Garnova
    • 1
    • 2
  • A. N. Grinev
    • 1
    • 2
  • N. G. Tsyshkova
    • 1
    • 2
  1. 1.Scientific-Research Institute of Medicinal RadiologyAcademy of Medical Sciences of the USSRObninsk
  2. 2.S. Ordzhonikidze All-Union Scientific-Research Pharmaceutical Chemistry InstituteMoscow

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