Abstract
Under the action of butyllithium, 1,2-dimethylimidazole is metallated in position 5. The reactions of 5-lithio-1,2-dimethylimidazole with N-bromodiethylamine, benzaldehyde, benzophenone, dimethylformamide, and ω-iodophenylacetylene have been performed.
References
K. Ziegler and H. Zeizer, Ann., 485, 174, 1931.
C. Courtot and S. Tchelicheff, C. r., 217, 231, 1943.
D. I. Brown, A. H. Cook, and I. Heilbron, J. Chem. Soc., S106, 1949.
A. M. Roe, J. Chem. Soc., 2195, 1963.
K. Hofmann, Imidazole and its Derivatives, Vol. 6, New York, 327, 1953.
H. Gilman, J. A. Beel, C. G. Brannen, M. W. Bullock, G. E. Dunn, and L. S. Miller, J. Am. Chem. Soc., 71, 1499, 1949.
G. Hedestrand, Z. Phys. Chem., B2, 428, 1929.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tertov, B.A., Burykin, V.V. & Sadekov, I.D. The metallation of 1,2-dimethylimidazole. Chem Heterocycl Compd 5, 418–419 (1969). https://doi.org/10.1007/BF00471164
Issue Date:
DOI: https://doi.org/10.1007/BF00471164