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Psychopharmacology

, Volume 78, Issue 1, pp 33–37 | Cite as

Factors involved in the differential response to ethanol, barbital and pentobarbital in rats selectively bred for ethanol sensitivity

  • Joel M. Mayer
  • Jatinder M. Khanna
  • Harold Kalant
  • Anita Chau
Original Investigations

Abstract

Two lines of rats, ‘least affected’ (LA) and ‘most affected’ (MA), had been selectively bred for their differential sensitivity to ethanol. Both males and females of the LA strain were observed to be less sensitive than their MA counterparts to the acute hypnotic and motor-impairing effects of ethanol. However, a lower ethanol metabolic rate of the MA males suggests that both CNS and metabolic factors contribute to their enhanced sensitivity to ethanol. By contrast, no differences were observed between the LA and MA males with respect to the hypnotic and subhypnotic effects of pentobarbital or to the clearance of this drug. MA females were more sensitive only to the hypnotic effects of pentobarbital, probably because of a smaller apparent volume of distribution. No strain difference was observed in the hypnotic effect or clearance of barbital. These observations suggest that, in spite of a differential sensitivity to ethanol, the LA and MA lines do not differ in their response to the barbiturates tested.

Key words

Ethanol sensitivity Barbiturate sensitivity Genetics 

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Joel M. Mayer
    • 1
    • 2
  • Jatinder M. Khanna
    • 1
    • 2
  • Harold Kalant
    • 1
    • 2
  • Anita Chau
    • 1
    • 2
  1. 1.Department of PharmacologyUniversity of TorontoTorontoCanada
  2. 2.Addiction Research Foundation of OntariotorontoCanada

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