Studies in the imidazole series
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A new synthesis of derivatives of imidazo[2,1-b]thiazole from 2-halogenoimidazoles has been effected. The reaction of 2-bromo-4,5-diphenylimidazoles with phenacyl bromide and its p-substituted derivatives has given the corresponding 2-bromo-1-phenylimidazoles, by the heating of which with thiourea and subsequent cyclization of the resulting 2-mercapto-1-phenacylimidazoles under the action of phosphorus oxychloride a number of 2,5,6-triarylimidazo[2,1-b]thiazoles has been synthesized.
KeywordsPhosphorus Bromide Organic Chemistry Imidazole Thiourea
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