Chemistry of Heterocyclic Compounds

, Volume 6, Issue 6, pp 763–765 | Cite as

Studies in the imidazole series

XLIX. Synthesis of derivatives of imidazo[2,1-b]thiazole
  • I. A. Mazur
  • P. M. Kochergin
  • G. S. Tkachenko
Article

Abstract

A new synthesis of derivatives of imidazo[2,1-b]thiazole from 2-halogenoimidazoles has been effected. The reaction of 2-bromo-4,5-diphenylimidazoles with phenacyl bromide and its p-substituted derivatives has given the corresponding 2-bromo-1-phenylimidazoles, by the heating of which with thiourea and subsequent cyclization of the resulting 2-mercapto-1-phenacylimidazoles under the action of phosphorus oxychloride a number of 2,5,6-triarylimidazo[2,1-b]thiazoles has been synthesized.

Keywords

Phosphorus Bromide Organic Chemistry Imidazole Thiourea 

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Copyright information

© Consultants Bureau 1973

Authors and Affiliations

  • I. A. Mazur
    • 1
    • 2
  • P. M. Kochergin
    • 1
    • 2
  • G. S. Tkachenko
    • 1
    • 2
  1. 1.Zaporozh'e Medical InstituteUSSR
  2. 2.Ordzhonikidze All-Union Chemical and Pharmaceutical Scientific-Research InstituteMoscow

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