Chemistry of Heterocyclic Compounds

, Volume 13, Issue 3, pp 307–311 | Cite as

Introduction of substituents in the pyridine proton of 7-azaindoline

  • D. M. Krasnokut-skaya
  • L. N. Yakhontov


Electropilic substitution (nitration, bromination, and chlorination) of 4-methyl-6-chloro-7-azaindoline (and its N-acetyl derivative) takes place in the 5 position. 4-Methyl-5-amino-7-azaindoline, 4-methyl-5-nitro-7-azaindoline, and 1-acetyl-4-methyl-5-amino-6-chloro-7-azaindoline were obtained by reduction of 1-acetyl-4-methyl-5-nitro-6-chloro-7-azaindoline under various conditions. A method was developed for the preparation of a new three-ring system — 1,2,3-oxadiazolo[5,4-b]-pyrrolo[2,3-e]pyridine.


Organic Chemistry Pyridine Nitration Pyridine Proton 
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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • D. M. Krasnokut-skaya
    • 1
  • L. N. Yakhontov
    • 1
  1. 1.S. Ordzhonikidze All-Union Scientific-Research Pharmaceutical-Chemistry InstituteMoscow

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