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structure of 4,4,6-trimethyl-2-mylamino-5,6-dihydro-4H-1,3-thiazines and -oxazines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

It is shown by means of IR, PMR, and UV spectra that 4,4,6-trimethyl-2-arylamino-5, 6-dihydro-4H-1,3-thlazines and 4,4,6-trimethyl-2-arylamino-5,6-dihydro-4H-1,3-oxazines in the crystalline state and in solution exist primarily in the amino form. It was found that ionization to give cations proceeds more readily in the case of 1,3-oxazines than in the case of 1,3-thiazines. In addition, a decrease in the ability to undergo intermolecular association and a decrease in the energy barrier to rotation about the N-heteroring bond are observed for 1,3-oxazines.

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Authors and Affiliations

  1. S. Ordzhonikidze All-Union Scientific-Research Pharmaceutical-Chemistry Institute, 119021, Moscow

    E. M. Peresleni, A. P. Engoyan, T. D. Zotova, Yu. N. Sheinker, L. A. Ignatova & B. V. Unkovskii

  2. M. V. Lomonosov Moscow Institute of Fine Chemical Technology, 119453, Moscow

    E. M. Peresleni, A. P. Engoyan, T. D. Zotova, Yu. N. Sheinker, L. A. Ignatova & B. V. Unkovskii

Authors
  1. E. M. Peresleni
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  2. A. P. Engoyan
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  3. T. D. Zotova
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  4. Yu. N. Sheinker
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  5. L. A. Ignatova
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  6. B. V. Unkovskii
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 346–352, March, 1977.

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Peresleni, E.M., Engoyan, A.P., Zotova, T.D. et al. structure of 4,4,6-trimethyl-2-mylamino-5,6-dihydro-4H-1,3-thiazines and -oxazines. Chem Heterocycl Compd 13, 278–284 (1977). https://doi.org/10.1007/BF00470310

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  • DOI: https://doi.org/10.1007/BF00470310

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