Abstract
The reaction of 1-alkyl-2-cyano (alkoxycarbonyl)methyl derivatives of imidazole and benzimidazole with α-halo ketones was studied. It was established that the presence of electron-acceptor substituents (CN, COOC2H5) in the methyl group in the 2 position of the imidazole ring markedly facilitates cyclization of the intermediate imidazolium and benzimidazolium halides to the corresponding cyano (alkoxycarbonyl) derivatives of pyrrolo[1,2-a]imidazoles and pyrrolo[1,2-a]benzimidazoles.
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See [6] for communication LXXXVIII.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1549–1551, November, 1976.
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Kochergin, P.M., Druzhinina, A.A. & Palei, R.M. Research in the imidazole series. Chem Heterocycl Compd 12, 1274–1276 (1976). https://doi.org/10.1007/BF00470231
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DOI: https://doi.org/10.1007/BF00470231