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Analogs of purine nucleosides and purine mono- and polynucleotides

VI. Phosphorylation of 9-(1, 5-Dihydroxy-3-Pentyl) Purines and their polycondensation with 1′, 5′-diphosphates of 6-Substituted 9- (1, 5-Dihydroxy-3-Pentyl) purines

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Abstract

Phosphorylation of 6-substituted 9-(1, 5-dihydroxy-3-pentyl)purines with 2-cyanoethyl phosphate in the presence of dicyclohexylcarbodiimide in anhydrous pyridine gave their 1′, 5′-diphosphates. Oligomers containing pyrophosphate and ester bonds were obtained by polycondensation of 1′, 5′-diphosphates of 6-dimethylamino- and 6-oxo-9-(1, 5-dihydroxy-3-pentyl)purines with the appropriate 9-(1, 5-dihydroxy-3-pentyl) purines.

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Literature cited

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Authors and Affiliations

  1. Institute of Organic Synthesis, Academy of Sciences of the Latvian SSR, Riga

    S. A. Giller†, A. Khettskhaim, I. A. Drizina & T. M. Krukle

Authors
  1. S. A. Giller†
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  2. A. Khettskhaim
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  3. I. A. Drizina
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  4. T. M. Krukle
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Additional information

See [1] for communication V.

Deceased.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 693–696, May, 1976.

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Giller†, S.A., Khettskhaim, A., Drizina, I.A. et al. Analogs of purine nucleosides and purine mono- and polynucleotides. Chem Heterocycl Compd 12, 582–586 (1976). https://doi.org/10.1007/BF00470118

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  • DOI: https://doi.org/10.1007/BF00470118

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