Advertisement

Fresenius' Zeitschrift für analytische Chemie

, Volume 332, Issue 4, pp 345–350 | Cite as

Determination of the drug content of pharmaceuticals containing phenothiazine compounds by triangle programmed flow titration

  • Zsófia Fehér
  • Ilona Kolbe
  • ErnŐ Pungor
Original Papers Pharmaceuticals

Summary

A flow-through triangle programmed coulometric titration technique is worked out for the determination of phenothiazine compounds. The oxidation reaction of phenothiazines with hypobromite ion served as titration reaction. A biamperometric detector cell has been used for following the titration process. The titration technique has been used for the determination of the drug content (average and individual) of chlorpromazine, promethazine, diethazine and trifluoperazine in pharmaceutical preparations. The relative standard deviation was in the range of 2.0 to 3.5%.

Keywords

Phenothiazine Drug Content Calibration Graph Trifluoperazine Coated Tablet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Bestimmung des Wirkstoffgehaltes von Phenothiazin-haltigen Pharmazeutica mit Hilfe einer Dreieck-programmierten Durchflu\-Titration

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ramappa PG, Gowda HS, Nayak AN (1979) Fresenius Z Anal Chem 298:160CrossRefGoogle Scholar
  2. 2.
    Morait G, Petroniu L, Popa C (1978) Farmacia 26:205Google Scholar
  3. 3.
    Szabolcs E (1980) Acta Pharm Hung 50:130Google Scholar
  4. 4.
    Stock JT (1965) Amperometric titrations. Interscience Publishers, New York London, p 524Google Scholar
  5. 5.
    Kabaskalian P, McGlotten J (1959) Anal Chem 31:431CrossRefGoogle Scholar
  6. 6.
    Pungor E, Fehér Zs, Nagy G (1971) Acta Chim Hung 70:207Google Scholar
  7. 7.
    Fehér Zs, Nagy G, Tóth K, Pungor E (1974) Analyst 99:699CrossRefGoogle Scholar
  8. 8.
    Takamura K, Irone S, Ito K, Kusu F (1986) Bunseki Kagaku 35:161CrossRefGoogle Scholar
  9. 9.
    Simonyi I, Zukovics J (1975) Acta Pharm Hung 42:250Google Scholar
  10. 10.
    Mohammed HY, Cantwell FF (1979) Anal Chem 51:1006CrossRefGoogle Scholar
  11. 11.
    Takahashi DM (1980) J Pharm Sci 69:184CrossRefGoogle Scholar
  12. 12.
    Beaulien W, Lawrence RC, Sears RW (1985) J Assoc Off Anal Chem 68:168Google Scholar
  13. 13.
    Kountourellis JE, Raptouli A, Georgarakis M (1986) Pharmazie 41:600Google Scholar
  14. 14.
    Cosofret VV, Buck RP (1984) Analyst 109:1321CrossRefGoogle Scholar
  15. 15.
    Nagy G, Fehér Zs, Tóth K, Pungor E (1977) Anal Chim Acta 91:87CrossRefGoogle Scholar
  16. 16.
    Nagy G, Fehér Zs, Tóth K, Pungor E (1977) Anal Chim Acta 91:97CrossRefGoogle Scholar
  17. 17.
    Nagy G, Fehér Zs, Tóth K, Pungor E (1978) Anal Chim Acta 100:181CrossRefGoogle Scholar
  18. 18.
    Fehér Zs, Nagy G, Tóth K, Pungor E, Tóth A (1979) Analyst 104:560CrossRefGoogle Scholar
  19. 19.
    Fehér Zs, Nagy G, Tóth K, Pungor E (1984) In: Pungor E (ed) Modern trends in analytical chemistry. Akadémiai Kiadó, Budapest, p 285Google Scholar
  20. 20.
    Fehér Zs, Kolbe I, Pungor E (1988) Analyst 113:881CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Zsófia Fehér
    • 1
  • Ilona Kolbe
    • 1
  • ErnŐ Pungor
    • 1
  1. 1.Technical Analytical Research Group of the Hungarian Academy of Sciences, Institute for General and Analytical ChemistryTechnical University of BudapestBudapestHungary

Personalised recommendations