Fresenius' Zeitschrift für analytische Chemie

, Volume 332, Issue 4, pp 345–350 | Cite as

Determination of the drug content of pharmaceuticals containing phenothiazine compounds by triangle programmed flow titration

  • Zsófia Fehér
  • Ilona Kolbe
  • ErnŐ Pungor
Original Papers Pharmaceuticals


A flow-through triangle programmed coulometric titration technique is worked out for the determination of phenothiazine compounds. The oxidation reaction of phenothiazines with hypobromite ion served as titration reaction. A biamperometric detector cell has been used for following the titration process. The titration technique has been used for the determination of the drug content (average and individual) of chlorpromazine, promethazine, diethazine and trifluoperazine in pharmaceutical preparations. The relative standard deviation was in the range of 2.0 to 3.5%.


Phenothiazine Drug Content Calibration Graph Trifluoperazine Coated Tablet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Bestimmung des Wirkstoffgehaltes von Phenothiazin-haltigen Pharmazeutica mit Hilfe einer Dreieck-programmierten Durchflu\-Titration


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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Zsófia Fehér
    • 1
  • Ilona Kolbe
    • 1
  • ErnŐ Pungor
    • 1
  1. 1.Technical Analytical Research Group of the Hungarian Academy of Sciences, Institute for General and Analytical ChemistryTechnical University of BudapestBudapestHungary

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