Chemistry of Heterocyclic Compounds

, Volume 3, Issue 5, pp 731–733 | Cite as

Transformations of imidazo[4, 5-f]quinoline

I. Action of methylating agents on imidazo[4, 5-f]quinoline and its 3-substituted derivatives
  • A. M. Simonov
  • B. I. Khristich
  • V. G. Poludnenko


Treatment of imidazo[4, 5-f]quinoline and some of its 3-substitmion products with methyl halides and methyl benzenesulfonate gives as the main reaction products N-methylimidazoquinolinium salts, which can also be synthesized from 5, 6-dimainoquinolines. Methylation at the N atom of the imidazole ring is only a side reaction. Treatment with trimethylphenylammonium hydroxide introduces a methyl radical into the NH group of imidazoquinoline, giving a mixture of 1-and 3-substitution products.


Methyl Hydroxide Organic Chemistry Imidazole Halide 
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Copyright information

© The Faraday Press, Inc. 1969

Authors and Affiliations

  • A. M. Simonov
    • 1
  • B. I. Khristich
    • 1
  • V. G. Poludnenko
    • 1
  1. 1.Rostov-on-Don State UniversityUSSR

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