Skip to main content
SpringerLink
Log in

T-cell dysfunction and hyperimmunoglobulinemia E in paracoccidioidomycosis

  • Published:
Mycopathologia Aims and scope Submit manuscript

Abstract

Various aspects of T and B cell mediated immunity were investigated in 20 well documented cases of active (10) or inactive (10) paracoccidioidomycosis (Pcm), as well as in 8 healthy individuals living in the endemic area of the disease. The results confirm previous reports that active Pcm produces diverse grades of depression of T cell mediated immunity. Such T cell dysfunction is not associated with a reduction in the number of peripheral E rosette-forming cells, and the immunodepression is reversed by chemotherapy. Sera from Pcm (active or inactive) patients have significantly increased levels of total IgE, but the actual proportion of IgE antibodies against P. brasiliensis was very low (0.4–0.6%). The highest levels of total IgE were found in active patients with disease-related immune depression, suggesting that T cell dysfunction might contribute to the excessive IgE production.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bach, J. F., 1973. Evaluation of T-cells and thymic serum factors in man using the rosette technique. Transplant. Rev. 16: 196–217.

    Google Scholar 

  2. Boyum, A., 1968. Separation of leukocytes from blood and bone marrow. Scand. J. Clin. Lab. Invest. 21; Suppl. 97: 31–50.

    Google Scholar 

  3. Conti-Díaz, I. A., Somma-Moreira, R. D., Gezuele, E., Giménez, A. C., Peña, M. I. & Mackinnon, J. E., 1973. Immunoelectroosmophoresis-immunodiffussion paracoccidioidomycosis. Sabouraudia 11: 39–41.

    Google Scholar 

  4. Correa, A. & Giraldo, R., 1972. Study of immune mechanisms in paracoccidioidomycosis. I. Changes of immunoglobulins (IgG, IgM and IgA). Proc. First Pan. Am. Symp. Paracoccidioidomycosis. PAHO Sci. Publ. 254: 245–250.

    Google Scholar 

  5. Cox, R. A. & Arnold, D. R., 1979. Immunoglobulin E in coccidioidomycosis. J. Immunol. 123: 194–200.

    Google Scholar 

  6. Dessaint, J. P., Capron, M., Bout, D. & Capron, A., 1975. Quantitative determination of specific IgE antibodies to schistome antigens and serum IgE levels in patients with schistosomiasis (S. mansoni or S. haematobium). Clin. Exp. Immunol. 20: 427–436.

    Google Scholar 

  7. Engvall, E. & Perlman, P., 1971. Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. Immunochemistry 8: 871–874.

    Google Scholar 

  8. Fonseca, O. & Area Leao, A. E., 1927. Reaction cutanée spécifique avec le filtrat de cultures de Coccidioides immitis. Compt. Rend. Soc. Biol. (Paris) 97: 1796–1797.

    Google Scholar 

  9. Goihman-Yarh, M., Pine, L., Albornoz, M. C., Yarzábal, L., Gómez, M. H., San Martin, B., Ocanto, A., Molina, T. & Convit, J., 1980. Studies on plating efficiency and estimation of viability of suspensions of Paracoccidioides brasiliensis yeast cells. Mycopathologia 71: 73–83.

    Google Scholar 

  10. Jones, H. E., Reinhardt, J. H. & Rinaldi, M. G., 1974. Immunologic susceptibility to chronic dermatophytosis. Arch. Dermatol., 119: 213–218.

    Google Scholar 

  11. Lacaz, C. S., Passos Filho, M. C. R. & Fava-Netto, C., 1959. Contribuicao para o estudo da blastomicose infecca o: estudo serológico e clinico-radiologico dos paracoccidioidino positivos. Rev. Inst. Med. Trop. Sao Paulo 1: 245–259.

    Google Scholar 

  12. Londero, A. T., 1975. Epidemiologia da paracoccidioidomicose. Ars. Curandi 7: 14–22.

    Google Scholar 

  13. Londero, A. T. & Ramos, C. D., 1972. Paracoccidioidomycosis. A clinical and mycological study of 41 cases observed in Sta. María, R. S., Brazil. Am. J. Med. 52: 771–775.

    Google Scholar 

  14. Machado-Filho, J., Miranda, J. L. & Teixeira, G., 1965. Das sequelas da blastomicose sul-americana. O'Hospital 68: 1347–1353.

    Google Scholar 

  15. Mackinnon, J. E., 1959. Pathogenesis of South-American blastomycosis. Trans. Roy. Soc. Trop. Med. Hyg. 53: 487–494.

    Google Scholar 

  16. Mackinnon, J. E., Artagaveytia-Allende, R. C. & Arroyo, L., 1953. Sobre la especificidad de la intradermo-reacción con paracoccidioidina. An. Fac. Med. Montevideo 38: 363–382.

    Google Scholar 

  17. Mancini, G., Carbonara, A. O. & Heremans, J. F., 1965. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 2: 235–254.

    Google Scholar 

  18. Mathur, S. J., Goust, J. M., Horger, E. O. & Fudenberg, H. H., 1977. Immunoglobulin E anti-Candida antibodies and candidiasis. Infect. Immun. 18: 257–259.

    Google Scholar 

  19. Mendes, N. E., Musatti, C. C., Leao, R. C., Mendes, E. & Naspitz, C. K., 1971. Lymphocyte cultures and skin allograft survival in patients with South American blastomycosis. J. Allergy Clin. Immunol. 48: 40–45.

    Google Scholar 

  20. Mendes, E. & Raphael, A., 1971. Impaired delayed hypersensitivity in patients with South American blastomycosis. J. Allergy 47: 17–22.

    Google Scholar 

  21. Merino, F. & Brand, A., 1977. Immunological studies in onchocercosis patients. Tropenmed. Parasit. 28: 229–234.

    Google Scholar 

  22. Mok, P. W. Y. & Greer, D. L., 1977. Cell-mediated immune responses in patients with paracoccidioidomycosis. Clin. Exp. Immunol. 28: 89–98.

    Google Scholar 

  23. Mota, F. T. & Franco, J. F., 1979. Observaçoes sobre e pesquisa de anticorpos IgM anti-Paracoccidioides brasiliensis, por immunofluorescencia no soro de pacientes con paracoccidioidomicose. Rev. Inst. Med. Trop. Sao Paulo 21: 82–89.

    Google Scholar 

  24. Musatti, C. C., Rezkallah, M. T., Mendes, E. & Mendes, N. F., 1976. In vivo and in vitro evaluation of cell-mediated immunity in patients with paracoccidioidomycosis. Cell Imm. 24: 365–378.

    Google Scholar 

  25. Negroni, P. & Negroni, R., 1965. Nuestra experiencia de la blastomicosis sudamericana en la Argentina. Mycopathol Mycol Appl. 26: 264–272.

    Google Scholar 

  26. Rea, T. H., Einstein, H. & Levan, N. E., 1976. Dinitrochlorobenzene responsivity in disseminated coccidioidomycosis: an inverse correlation with complement-fixing antibody titres. J. Invest. Dermatol. 66: 34–37.

    Google Scholar 

  27. Restrepo, A., 1970. A reappraisal of the microscopical appearance of the mycelial phase of P. brasiliensis. Sabouraudia 8: 141–144.

    Google Scholar 

  28. Restrepo, A., 1978. Paracoccidioidomicosis. Acta Méd. Col. 1: 33–36.

    Google Scholar 

  29. Restrepo, A., Restrepo, M., Restrepo, F., Aristizábal, L. H., Moncada, L. H. & Velez, H., 1978. Immune responses in paracoccidioidomycosis. A controlled study of 16 patients before and after treatment. Sabouraudia 16: 151–163.

    Google Scholar 

  30. Restrepo, A., Robledo, M., Ospina, S. C., Restrepo, M. & Correa, A., 1968. Distribution of paracoccidioidin sensitivity in Colombia. Am. J. Trop. Med. Hyg. 17: 25–37.

    Google Scholar 

  31. Restrepo, A. & Schneidau, J. A., 1967. Nature of the skinreactive principle in culture filtrates prepared from Paracoccidioides brasiliensis. J. Bact. 93: 1741–1748.

    Google Scholar 

  32. Waldorf, D. S., Sheagren, J. N. & Trautman, J. R., 1966. Impaired delayed hypersensitivity in patients with lepromatous leprosy. Lancet 2: 773–777.

    Google Scholar 

  33. Yarzábal, L. A., Albornoz, M. C. B., Cabral, N. A. & Santiago, A. R., 1978. Specific double diffusion microtechnique for the diagnosis of aspergillosis and paracoccidioidomycosis using monospecific antisera. Sabouraudia 16: 55–62.

    Google Scholar 

  34. Yarzábal, L. A., Dessaint, J. P., Arango, M., Albornoz, M. C. B. & Campins, H., 1980. Demonstration and quantification of IgE antibodies against Paracoccidoides brasiliensis in paracoccidioidomycosis. Int. J. Allergy Appl. Immun. 62: 346–351.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sección de Inmunología Parasitaria, CEPIALET, OPS/OMS, Instituto Nacional de Dermatología, Apartado postal 4043, 1010 A, Caracas, Venezuela

    M. Arango & L. Yarzábal

Authors
  1. M. Arango
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. Yarzábal
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Arango, M., Yarzábal, L. T-cell dysfunction and hyperimmunoglobulinemia E in paracoccidioidomycosis. Mycopathologia 79, 115–123 (1982). https://doi.org/10.1007/BF00468089

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00468089

Keywords

Search

Navigation