Fresenius' Zeitschrift für analytische Chemie

, Volume 301, Issue 2, pp 114–114 | Cite as

Monitoring of serum or saliva theophylline concentrations by a new radioimmunoassay

  • K. Zech
  • K. Borner
  • O. v. Stetten
Toxicology and Drug Monitoring

Conclusions

The new radioimmunoassay RIA-mat Theophylline appeared to be highly specific, as none of the drugs structurally related to theophylline or other substances tested showed a noticeable cross reaction. Precision and accuracy are better than comparable assays, the sensitivity of detection is much better than e.g. if using an enzyme immunoassay.

Since the required reagents are available as ready-to-use solutions, it is possible to run individual determinations e.g. in emergency cases, as well as large series in a very brief period of time.

Key words

Best. von Theophyllin in Blutserum, Speichel Radioimmunoassay 

Bestimmung von Theophyllin-Konzentrationen in Serum oder Speichel mit einem neuen Radioimmunoassay

References

  1. 1.
    Aranda, J. V., Sitar, D. S., Parson, W. D., Longhan, P. M., Neims, A. H.: Clin. Res. 23, 608 (1975)Google Scholar
  2. 2.
    Herrmann, G., Aynesworth, M. B.: J. Lab. Clin. Med. 23, 135–148 (1937)Google Scholar
  3. 3.
    Wilson, A. F., McPhillips, J. J.: Ann. Rev. Pharmacol. Toxicol. 18, 541 (1978)Google Scholar

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • K. Zech
    • 1
    • 2
    • 3
  • K. Borner
    • 1
    • 2
    • 3
  • O. v. Stetten
    • 1
    • 2
    • 3
  1. 1.Byk Gulden PharmaceuticalsKonstanz
  2. 2.Klinikum Steglitz der Freien Universität BerlinDeutschland
  3. 3.Byk Mallinckrodt DiagnosticsDietzenbachDeutschland

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