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Adrenergic-receptor desensitization and course of clinical improvement with desipramine treatment

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Abstract

α2-Adrenergic receptor sensitivity was assessed during desipramine treatment by carefully monitoring clonidine-induced blood pressure changes, as well as symptomatology, in three patients with major depressive disorder. The data appear to be consistent with the hypothesis that the antidepressant action of desipramine is mediated by α2-autoreceptor desensitization.

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References

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Authors and Affiliations

  1. Psychiatry Service, Veterans Administration Medical Center, Cincinnati, Ohio, USA

    Michael L. Mavroidis, Donald R. Kanter, David N. Greenblum & David L. Garver

  2. Department of Psychiatry, University of Cincinnati, Ohio, USA

    Michael L. Mavroidis, David N. Greenblum & David L. Garver

  3. Department of Pharmacology and Cell Biophysics, University of Cincinnati, Ohio, USA

    David L. Garver

Authors
  1. Michael L. Mavroidis
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  2. Donald R. Kanter
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  3. David N. Greenblum
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  4. David L. Garver
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Mavroidis, M.L., Kanter, D.R., Greenblum, D.N. et al. Adrenergic-receptor desensitization and course of clinical improvement with desipramine treatment. Psychopharmacology 83, 295–296 (1984). https://doi.org/10.1007/BF00464799

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  • DOI: https://doi.org/10.1007/BF00464799

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