Psychopharmacology

, Volume 83, Issue 3, pp 272–276 | Cite as

Alcohol increases both locomotion and immobility in mice: An ethological analysis of spontaneous motor activity

  • Robert Smoothy
  • Michael S. Berry
Original Investigations

Abstract

The effects of alcohol on locomotor activity of group- and individually-housed mice were studied using direct ethological observations, including a detailed postural analysis and measures of both locomotion and immobility. Ethanol (0, 0.5, 1.0 and 2.0 g/kg, IP) was given to subjects placed alone in a novel cage, and videotape recordings of behaviour were made. Locomotor activity was unchanged or increased by alcohol administration. Immobility was profoundly increased, however, at both the intermediate and high doses of alcohol, so that there was a simultaneous increase in measures of both locomotion and immobility. These increases were possible because of a decrease in certain active but non-locomotor elements of behaviour, such as rearing and digging. There generally appeared to be little effect of differential housing, although blood alcohol levels were significantly higher in group-housed animals. This depressant effect of alcohol would probably not be detected by simply recording locomotor activity, since ambulation itself was unchanged or increased. Measurements of both locomotion and immobility may thus more accurately detect stimulant and depressant effects of drugs.

Key words

Ethanol Locomotor activity Ethological analysis Immobility Mice 

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References

  1. Bücher T, Redetzki H (1951) Eine spezifische photometrische Bestimmung von Äthylalkohol auf fermentativem Wege. Klin Wschr 29:615–616Google Scholar
  2. Cutler MG, Mackintosh JH (1975) Effects of delta-9-tetrahydrocannabinol on social behaviour in the laboratory mouse and rat. Psychopharmacologia 44:287–289Google Scholar
  3. Cutler MG, Mackintosh JH, Chance MRA (1975a) Effects of the environment on the behavioural response of mice to non-ataxic doses of ethyl alcohol. Neuropharmacology 14:841–846Google Scholar
  4. Cutler MG, Mackintosh JH, Chance MRA (1975b) Effects of cannabis resin on the social behaviour of the laboratory mouse. Psychopharmacologia 41:271–276Google Scholar
  5. Daniel WW (1978) Applied nonparametric statistics. Houghton Mifflin Company, BostonGoogle Scholar
  6. Frye GD, Breese GR (1981) An evaluation of the locomotor stimulating action of ethanol in rats and mice. Psychopharmacology 75:372–379Google Scholar
  7. Grant EC, Mackintosh JH (1963) A description of the social postures of some common laboratory rodents. Behaviour 21: 246–259Google Scholar
  8. Irwin S, Kinohi R, Van Sloten M, Workman MP (1971) Drug effects on distress-evoked behavior in mice: methodology and drug class comparisons. Psychopharmacologia 20:172–185Google Scholar
  9. Kelly PH (1977) Drug-induced motor behaviour. In: Iversen LL, Iversen SD, Snyder SH (eds) Handbook of psychopharmacology, vol 8. Plenum Press, New York, pp 295–331Google Scholar
  10. Kršiak M (1976) Effect of ethanol on aggression and timidity in mice. Psychopharmacology 51:75–80Google Scholar
  11. Kršiak M, Borgesová M (1972) Drugs and spontaneous behaviour: why are detailed studies still so rare? Act Nerv Super (Praha) 14:285–293Google Scholar
  12. Kršiak M, Borgesová M (1973) Effect of alcohol on behaviour of pairs of rats. Psychopharmacologia 32:201–209Google Scholar
  13. Kršiak M, Steinberg H, Stolerman IP (1970) Uses and limitations of photocell activity cages for assessing effects of drugs. Psychopharmacologia 17:258–274Google Scholar
  14. Liljequist S, Engel J (1980) Effect of ethanol on central GABAergic mechanisms. In: Eriksson K, Sinclair JD, Kiianmaa K (eds) Animal models in alcohol research. Academic Press, London, pp 309–315Google Scholar
  15. Liljequist S, Engel J (1982) Effects of GABAergic agonist and antagonists on various ethanol-induced behavioural changes. Psychopharmacology 78:71–75Google Scholar
  16. Mackintosh JH, Chance MRA, Silverman AP (1977) The contribution of ethological techniques to the study of drug effects. In: Iversen LL, Iversen SD, Snyder SH (eds) Handbook of psychopharmacology, vol 7. Plenum Press, New York, pp 3–35Google Scholar
  17. Miczek KA, O'Donnell J (1980) Alcohol and chlordiazepoxide increase suppressed aggression in mice. Psychopharmacology 69:39–44Google Scholar
  18. Middaugh LD, Read E, Boggan WO (1978) Effects of naloxone on ethanol induced alterations of locomotor activity in C57 BL/6 mice. Pharmacol Biochem Behav 9:157–160Google Scholar
  19. Miller S (1975) Experimental design and statistics. Methuen, LondonGoogle Scholar
  20. Read GW, Cutting W, Furst A (1960) Comparison of excited phases after sedatives and tranquilizers. Psychopharmacologia 1:346–350Google Scholar
  21. Robbins TW (1977) A critique of the methods available for the measurement of spontaneous motor activity. In: Iversen LL, Iversen SD, Snyder SH (eds) Handbook of psychopharmacology, vol 7. Plenum Press, New York, pp 37–82Google Scholar
  22. Rodgers RJ (1981) Drugs, aggression and behavioural methods. In: Brain PF, Benton D (eds) Multidisciplinary approaches to aggression research. Elsevier/North-Holland Biomedical Press, Amsterdam, pp 325–340Google Scholar
  23. Smoothy R, Berry MS (1983) Effects of ethanol on behaviour of aggressive mice from two different strains: a comparison of simple and complex behavioural assessments. Pharmacol Biochem Behav 19:645–653Google Scholar
  24. Smoothy R, Bowden NJ, Berry MS (1982) Ethanol and social behaviour in naive Swiss mice. Aggr Behav 8:204–207Google Scholar
  25. Strömbom UF, Liedman B (1982) Role of dopaminergic neurotransmission in locomotor stimulation by dexamphetamine and ethanol. Psychopharmacology 78:271–276Google Scholar
  26. Tedeschi DM, Fowler PJ, Cromley WH, Pauls JF, Eby RZ, Fellows EJ (1964) Effects of centrally acting drugs on confinement motor activity. J Pharm Sci 53:1046–1050Google Scholar
  27. Winer BJ (1971) Statistical principles in experimental design, 2nd edn. McGraw-Hill, TokyoGoogle Scholar

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Robert Smoothy
    • 1
  • Michael S. Berry
    • 1
  1. 1.Department of ZoologyUniversity College of SwanseaSwanseaWales, UK

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