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Examination and classification of human olfactory mucosa in patients with clinical olfactory disturbances

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Summary

To determine objectively the degree of olfactory disturbance, we biopsied the olfactory mucosa from patients who complained of anosmia. The olfactory disturbances in this study were caused by choanal atresia, chronic sinusitis, viral inflammation, and head trauma, as well as by congenital and idiopathic anosmia. The biopsy specimens were examined by light microscopy and the degree of mucosal degeneration present was classified according to five grades. The clinical courses of the patients studied paralleled the changes found in the olfactory mucosa.

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References

  1. Graziadei PPC, Karlan MS, Graziadei GAM, Berstein JJ (1980) Neurogenesis of sensory neurons in the primate olfactory system after section of the filia olfactoria. Brain Res 186:289–300

    Google Scholar 

  2. Hasegawa S, Yamagishi M, Nakano Y (1986) Microscopic studies of human olfactory epithelia following traumatic anosmia. Arch Otorhinolaryngol 243:112–116

    Google Scholar 

  3. Igarashi Y, Oka Y, Ishizuka Y (1986) Electron microscopic observations of the nasal olfactory area in Kallmann syndrome. Prac Otol (Kyoto) 79:2041–2048

    Google Scholar 

  4. Lovell MA, Jafec BW, Moran DT, Rowley C (1982) Biopsy of human olfactory mucosa. An instrument and technique. Arch Otolaryngol 108:247–249

    Google Scholar 

  5. Matulionis DH, Breipohl W, Bhatnagar KP (1982) Degeneration and regeneration of olfactory epithelium in the mouse. A scanning electron microscopic study. Ann Otol Rhinol Laryngol [Suppl 89] 91:1–12

    Google Scholar 

  6. Moran DT, Jafec BW, Rowley JC, Eller PM (1985) Electron microscopy of olfactory epithelia in two patients with anosmia. Arch Otolaryngol 111:122–126

    Google Scholar 

  7. Takagi S (1987) A standardized olfactometer in Japan. A review over ten years. In: Roper SD, Atema J (eds) Olfaction and taste IX. New York Academy of Sciences, New York, pp 113–118

    Google Scholar 

  8. Yamagishi M, Hasegawa S, Takahashi S, Nakano Y, Iwanaga T (1987) Immunohistochemical method for the diagnosis of olfactory disturbance. Acta Otolaryngol (Stockh) 103:145–150

    Google Scholar 

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Authors and Affiliations

  1. Department of Otolaryngology, Niigata University School of Medicine, Asahi-machi 1, 951, Niigata City, Japan

    M. Yamagishi, S. Hasegawa & Y. Nakano

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  1. M. Yamagishi
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  2. S. Hasegawa
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  3. Y. Nakano
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Yamagishi, M., Hasegawa, S. & Nakano, Y. Examination and classification of human olfactory mucosa in patients with clinical olfactory disturbances. Arch Otorhinolaryngol 245, 316–320 (1988). https://doi.org/10.1007/BF00464640

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  • DOI: https://doi.org/10.1007/BF00464640

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