Summary
The effect of HR-6 solutions containing adenosine triphosphate (either 0.5 or 5 mg/ml) and placebo on the symptoms of chronic rhinitis was studied in 11 patients in randomized, crossover study. The nasal mucociliary activity present in these patients was measured by a radioisotopic method and was impaired in all patients, varying from 1.4 to 5.5 mm/min with a mean of 3.2 mm/min. The duration of each treatment was 10 days, with wash-out periods of 4 days. The relief of the nasal symptoms was recorded. The active drugs on average improved nasal mucociliary activity by 1.9–2.1 mm/min against placebo (1.4 mm/min). At the end of the trial six patients preferred the active drugs for relief of nasal symptoms, none placebo and five had no preferences. The results indicate the need for long-term studies of HR-6 in patients with impaired mucociliary function.
Similar content being viewed by others
References
Afzelius BA (1976) A human syndrome caused by immotile cilia. Science 193:317–319
Forrest JB, Rossman CM, Newhouse MT, Ruffin R (1979) Activation of nasal cilia in immotile cilia syndrome. Am Rev Respir Dis 120:511–515
Kärjä J, Nuutinen J, Karjalainen P (1982) Radioisotopic method for measurement of nasal mucociliary activity. Arch Otolaryngol 108:99–101
Lewis FH, Beals TF, Carey TE, Baker SR, Matthews KP (1983) Ultrastructural and functional studies of cilia from patients with asthma, aspirin intolerance and nasal polyps. Chest 83:487–490
Nuutinen J (1985) Activation of impaired nasal mucociliary function. A preliminary clinical study. Acta Otolaryngol (Stockh) 99:605–609
Nuutinen J, Kärjä J, Karjalainen P (1983) Measurements of impaired mucociliary activity in children. Eur J Respir Dis 64 [Suppl 128]:454–456
Pedersen H, Mygind N (1976) Absence of axonemal arms in nasal mucosa cilia in Kartagener's syndrome. Nature 262:494–495
Robert J, Laurens MH, Simeons P, Thouvenot P, Wayoff M (1980) Etude du drainage mocociliare nasal par méthode radioisotopique. Pathol Biol 28:181–184
Rossman CM, Forrest JB, Ruffin RE, Newhouse MT (1980) Immotile cilia syndrome in persons with and without Kartagener's syndrome. Am Rev Respir Dis 121: 1011–1016
Saano V, Muranen A, Virta P, Nuutinen J, Karttunen P (1987) ATP in vitro stimulates the ciliary activity and in vivo antagonizes the depresant effect of benzalkonium chloride on ciliary activity in rat trachea. Xth International Congress of Pharmacology, Sydney, Australia, August 23–28. Abstract Book, Abstract P1327
Sturgess JM, Chao J, Wong J, Norman A, Turner P (1979) Cilia with defective radial spokes: a cause of human respiratory disease. N Engl J Med 300:53–56
Takasaka T, Sato M, Onodera A (1980) Atypical cilia of the human nasal mucosa. Ann Otol Rhinol Laryngol 89:37–45
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nuutinen, J., Karttunen, P. & Silvasti, M. Activation of mucociliary function in chronic rhinitis: a placebo-controlled study. Arch Otorhinolaryngol 245, 284–286 (1988). https://doi.org/10.1007/BF00464631
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00464631