Summary
A human embryo of 14 mm crown-rump length is described to exemplify the anomaly of double outlet right ventricle with subaortic defect. The configuration of endocardial swellings in the outflow portion of the heart are compatible with the general architecture of full-grown examples of the anomaly. This configuration differs considerably from normal embryonic anatomy, but is still supported by the architecture of the myoepicardial mantle. It is concluded that endocardial swellings play a secondary role in the determination of fullgrown cardiac anatomy.
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Anderson, R.H., Wilkinson, J.L., Arnold, R., Becker, A.E., Lubkiewicz, K.: Morphogenesis of bulboventricular malformations. II. Observations on malformed hearts. Br. Heart J. 36, 948–970 (1974)
Becker, A.E., Connor, M., Anderson, R.H.: Tetralogy of Fallot: a morphometric and geometric study. Am. J. Cardiol. 35, 402–412 (1975)
Bersch, W.: On the importance of the bulboauricular flange for the formal genesis of congenital heart defects with special regard to the ventricular septum defects. Virchows Arch. Abt. A Path. Anat. 354, 252–267 (1971)
Bersch, W., Chuaqui, B.J., Hellmann, K.: Persistenz des primitiven Aortenconus bei regelrechter Stellung der gro\en GefÄ\e des Herzens. Ein Beitrag zur formalen EinstÄndigkeit der Bulbusschrumpfungshemmung. Virchows Arch. A Path. Anat. and Histol. 368, 299–307 (1975)
Doerr, W.: über ein formales Prinzip der Koppelung von Entwicklungsstörungen der venösen und arteriellen Kammerostien. Z. Kreislauff. 41, 269–284 (1952)
Edwards, J.E.: Origin of both great vessels from right ventricle (double-outlet right ventricle). In: Pathology of the heart and blood vessels. (Gould, S.E. ed.) pp. 396–398. Springfield, Illinois: Charles C. Thomas 1968
Goerttler, K.: über Blutstromwirkung als Gestaltungsfaktor für die Entwicklung des Herzens. Beitr. Path. Anat. 115, 33–56 (1955)
Grant, R.P.: The embryology of ventricular flow pathways in man. Circulation 25, 756–779 (1962)
Hollman, A.: The origin of both great arteries from the right ventricle. In: Paediatric Cardiology. (Watson, H. ed.) pp. 622–631. London: Lloyd Luke Ltd. 1968
Lev, M., Bharati, S., Meng, C.C.L., Liberthson, R.R., Paul, M.H., Idriss, F.: A concept of doubleoutlet right ventricle. J. Thorac. Cardiovasc. Surg. 64, 271–281 (1972)
Los, J.A.: Analysis of persistent interventricular communication in a human embryo of 19.8 mm CR-length. Acta Morphol. Neerl.-Scand. 9, 179–206 (1972)
Pexieder, T.: Cell death in the morphogenesis and teratogenesis of the heart. Adv. Anat. Embryol. Cell Biol. 51, 1–100 (1975)
Sridaromont, S., Feldt, R.H., Ritter, D.G., Davis, G.D., Edwards, J.E.: Double outlet right ventricle: hemodynamic and anatomic correlations. Am. J. Cardiol. 38, 85–94 (1976)
Streeter, G.L.: Developmental horizons in human embryos. Description of age groups XV, XVI, XVII and XVIII. Contrib. Embryol. 211, 133–204 (1948)
Van Gils, F.A.W.: The formation of the atrioventricular heart valves. Acta Morphol. Neerl.-Scand. 16, 151 (1978).
Wenink, A.C.G.: Some details on the final stages of heart septation in the human embryo. Thesis from Department of Anatomy, Leiden (1971)
Wenink, A.C.G.: The medial papillary complex. Br. Heart J. 39, 1012–1018 (1977)
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Wenink, A.C.G. Double outlet right ventricle in a human embryo. Virchows Arch. A Path. Anat. and Histol. 379, 313–320 (1978). https://doi.org/10.1007/BF00464474
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DOI: https://doi.org/10.1007/BF00464474