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Archives of oto-rhino-laryngology

, Volume 217, Issue 4, pp 409–413 | Cite as

Protein and isoamylase content of rat-submaxillary gland under the influence of α- and β-sympathicolysis

  • C. Arglebe
  • R. Chilla
Article

Summary

In order to study the function of adrenergic receptors in the submaxillary gland in vivo, rats were treated with the α-sympathicolytic, phentolamine (Regitin®) and with the β-sympathicolytic, propranolol (Dociton®) and the protein, amylase, and isoamylase content of their submaxillary glands were investigated. The protein concentration rises after 3 weeks of α- as well as combined α-and β-sympathicolysis while the amylase concentrations remain, on the whole, unchanged. The pharmacologically induced secretory inhibitions are being discussed in connection with the generally accepted receptor functions.

Key words

Sympathicolysis α-Amylase Rat-submaxillary gland Phentolamine Propranolol 

Zusammenfassung

Um die Funktion adrenergischer Rezeptoren in der Submandibularis in vivo zu untersuchen, behandelten wir Ratten mit dem α-Sympatholytikum Phentolamin (Regitin®) und dem β-Sympatholytikum Propranolol (Dociton®). Protein-, Amylase- und Isoamylasengehalt der Drüsen wurden untersucht. Auf dem 1%-Signifikanzniveau steigt der Proteingehalt der Submandibularis nach 3wöchiger α-Blockade wie auch nach kombinierter α- und β-Blokkade. Die Amylasekonzentrationen bleiben im wesentlichen unverändert. Die pharmakologisch induzierten Sekretionsstörungen werden im Zusammenhang mit bekannten Rezeptorfunktionen diskutiert.

Schlüsselwörter

Sympathicolyse α-Amylase Gl. submandibularis der Ratte Phentolamin Propranolol 

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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • C. Arglebe
    • 1
  • R. Chilla
    • 1
  1. 1.Universitäts-HNO-Klinik GöttingenGöttingenFederal Republic of Germany

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