European Journal of Pediatrics

, Volume 121, Issue 1, pp 15–20 | Cite as

Oral antipyretic therapy

Evaluation of benorylate, an ester of acetylsalicylic acid and paracetamol
  • S. Similä
  • S. Keinänen
  • K. Kouvalainen


The capacity of benorylate, an ester of acetylsalicylic acid and paracetamol, to reduce fever in children was compared with that of the components as such or as a combination. The series of cases studied consisted of 66 patients between the ages of 4 months and 12 years with rectal temperatures above 38.5°C. Temperatures were recorded at 15 and 20 min and 1, 2, 4 and 6 hrs after the administration of the drug.

The antipyretic effect of combined acetylsalicylic acid (11 mg/kg) and paracetamol (14 mg/kg) was superior to the effect of benorylate with a dose of 25 mg/kg and even of 50 mg/kg as well as better than the effect of either drug alone.

Acetylsalicylic acid (10 mg/kg) and paracetamol (12.5 mg/kg) alone produced a significantly greater antipyretic effect than benorylate with a dose of 25 mg/kg.

Given in a dose of 35–40 mg/kg, benorylate seems to have a significant antipyretic effect. However, this effect is clearly smaller than that of either of its components, acetylsalicylic acid or paracetamol. Therefore benorylate is probably not suitable to be used as a general antipyretic agent in children.

Key words

Benorylate Acetylsalicylic acid Paracetamol Antipyretic drugs Fever 


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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • S. Similä
    • 1
  • S. Keinänen
    • 1
  • K. Kouvalainen
    • 1
  1. 1.Department of PediatricsUniversity of OuluOuluFinland

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