Skip to main content

An experimental study of mucociliary pathology of the eustachian tube in otitis media with effusion induced by irradiation

Archives of oto-rhino-laryngology volume 246, pages 428–432 (1989)Cite this article

Summary

We have examined the function and fine structure of the mucociliary system of the eustachian tube in an experimental study of otitis media with effusion induced by X-ray irradiation. Functional examination demonstrated that the ciliary activity was diminished in such a condition, while morphological observations showed pathological findings including compound cilia, vacuolation of ciliated cells and expansion of intercellular space. These findings show that irradiation-induced otitis media with effusion results in impairment of the mucociliary system. As evidenced by these studies, the mucociliary system in the eustachian tube has an important role in the clearance of fluid produced in the tympanic cavity as well as affording improvement in this disease.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

References

  1. Beck JMH, Kuijpers W (1984) The mucoperiosteum of the middle ear experimentally induced sterile otitis media. Acta Otolaryngol [Suppl] (Stockh) 414:71–79

    Google Scholar 

  2. DeMaria TF, Briggs BR, Lim DJ, Okazaki N (1984) Experimental otitis media with effusion following middle ear inoculation of nonviable H. influenzae. Ann Otol Rhinol Laryngol 93:52–56

    Google Scholar 

  3. Harvey RM (1975) Environmental factors in glue ear. J Laryngol Otol 89:73–77

    Google Scholar 

  4. Lim DJ, Klainer A (1971) Cellular reactions in acute otitis media — scanning electron microscopy. Laryngoscope 81:772–786

    Google Scholar 

  5. Nonomura N, Nakano Y, Satoh Y, Fujioka H, Niijima H, Fujita M (1986) Otitis media with effusion following inoculation of Haemophilus influenzae type b endotoxin. Arch Otorhinolaryngol 243:31–35

    Google Scholar 

  6. Ohashi Y, Nakai Y (1983) Functional and morphological studies on chronic sinusitis mucous membrane. 1. Reduced ciliary action in chronic sinusitis. Acta Otolaryngol [Suppl] (Stockh) 397:3–8

    Google Scholar 

  7. Ohashi Y, Nakai Y (1984) Mucociliary activities in fetal rabbits. Acta Otolaryngol (Stockh) 97:351–358

    Google Scholar 

  8. Ohashi Y, Nakai Y, Kihara S (1985) Ciliary activity of the middle ear lining in guinea pigs. Ann Otol Rhinol Laryngol 94:419–423

    Google Scholar 

  9. Ohashi Y, Nakai Y, Kihara S, Maruoka K, Ikeoka H, Uemura Y (1985) The ciliary activity of the middle ear lining — functional and morphological observation. Auris Nasus Larynx (Tokyo) 12:123–125

    Google Scholar 

  10. Ohashi Y, Nakai Y, Koshimo H, Esaki Y (1986) Ciliary activity in the in vitro tubotympanum. Arch Otorhinolaryngol 243:317–319

    Google Scholar 

  11. Ohashi Y, Nakai Y, Ikeoka H, Koshimo H, Esaki Y (1986) Mucosal pathology of the eustachian tube after exposure to sulfur dioxide. Arch Otorhinolaryngol 243:274–279

    Google Scholar 

  12. Ohashi Y, Nakai Y, Ikeoka H, Esaki Y, Koshimo H, Onoyama Y (1987) Mucosal pathology of an experimental otitis media with effusion after X-ray irradiation. Am J Otolaryngol 8:223–235

    Google Scholar 

  13. Ohashi Y, Nakai Y, Kihara S, Ikeoka H (1987) Effects of Staphylococcus aureus on the ciliary activity of the middle ear lining. Ann Otol Rhinol Laryngol 96:225–228

    Google Scholar 

  14. Ohashi Y, Nakai Y, Esaki Y, Ikeoka H, Koshimo H, Onoyama Y (1988) Acute effects of irradiation on middle ear. Ann Otol Rhinol Laryngol 97:173–178

    Google Scholar 

  15. Sade J (1967) Ciliary activity and middle ear clearance. Arch Otorhinolaryngol 86:128–135

    Google Scholar 

  16. Tos M, Widerhold M, Larsen P (1984) Experimental long-term tubal occlusion in cats. Acta Otolaryngol (Stockh) 97:580–592

    Google Scholar 

Download references

Author information

Affiliations

  1. Department of Otolaryngology, Osaka City University Medical School, 1-5-7 Asahimachi, Abeno-ku, 545, Osaka, Japan

    Y. Ohashi, Y. Nakai & Y. Esaki

  2. Department of Radiology, Osaka City University Medical School, 1-5-7 Asahimachi, Abeno-ku, 545, Osaka, Japan

    Y. Onoyama

Authors
  1. Y. Ohashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Y. Nakai
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Y. Esaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Y. Onoyama
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ohashi, Y., Nakai, Y., Esaki, Y. et al. An experimental study of mucociliary pathology of the eustachian tube in otitis media with effusion induced by irradiation. Arch Otorhinolaryngol 246, 428–432 (1989). https://doi.org/10.1007/BF00464303

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00464303

Key words

  • Otitis media with effusion
  • Mucociliary system
  • Eustachian tube
  • Electron microscopy