Archives of oto-rhino-laryngology

, Volume 244, Issue 3, pp 180–184 | Cite as

Light and electron microscopic studies of localized laryngeal amyloidosis

  • H. Nagata
  • T. Yoshihara
  • M. Nomoto
  • T. Kanda
  • T. Kaneko
  • Y. Yaku
Regular Contributions


We performed light and electron microscopic studies in a case of localized supraglottic laryngeal amyloidosis involving a 55-year-old woman. Tissue specimens were stained with hematoxylin and eosin, and alkaline Congo red with or without permanganate (KMnO4) treatment, and were also examined with peroxidase-antiperoxidase immunohistochemistry. Biopsy specimens from the epiglottis showed diffuse replacement of the subepithelial region by amyloid, which showed a typical green birefringence under polarized light. Tissue affinity for Congo red was persistent after the KMnO4 treatment. However, the tissue sections showed a positive reaction only to the anti-P component antibody. Electron microscopic studies revealed some disorders of the plasma cells, suggesting that these cells play an important role in focal production of amyloid fibrils.

Key words

Localized laryngeal amyloidosis Light microscopy Electron microscopy Immunohistochemistry 


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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • H. Nagata
    • 1
  • T. Yoshihara
    • 1
  • M. Nomoto
    • 1
  • T. Kanda
    • 1
  • T. Kaneko
    • 1
  • Y. Yaku
    • 2
  1. 1.Department of Otorhinolaryngology, School of MedicineChiba UniversityChibaJapan
  2. 2.Department of Head and Neck SurgeryTochigi Prefectural Cancer CenterUtsunomiyaJapan

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