Archives of oto-rhino-laryngology

, Volume 246, Issue 5, pp 328–332 | Cite as

The relationship between nuclear DNA content in salivary gland tumors and prognosis

Comparison of mucoepidermoid tumors and acinic cell tumors
  • K. Hamper
  • J. Caselitz
  • H. Arps
  • U. Askensten
  • G. Auer
  • G. Seifert
Head and Neck Surgery


Differences in prognosis between salivary gland mucoepidermoid tumors and acinic cell tumors were compared by means of conventional histopathological grading and nuclear DNA content which was assessed cytochemically by a scanning cytophotometric procedure. The mucoepidermoid tumors were found to show a stronger correlation between histopathological grading and prognosis than did the acinic cell tumors. By using DNA quantification, valuable additional information could be obtained for predicting the behavior of the mucoepidermoid tumors, whereas there was no correlation between DNA content and prognosis for the acinic cell tumors. Regarding the relatively “benign” clinical course of most mucoepidermoid tumors, the term “tumor” — as proposed by the World Health Organization's classification — seems appropriate. In contrast, the more severe clinical courses of the acinic cell tumors justify the use of the term “carcinoma” instead.

Key words

Salivary gland tumors DNA assessment Prognosis Acinic cell tumor Mucoepidermoid tumor 


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  1. 1.
    Abrams AM, Cornyn J, Scofield HH, Hansen LS (1965) Acinic cell adenocarcinoma of the major salivary glands: a clinicopathologic study of 77 cases. Cancer 18:1145–1162Google Scholar
  2. 2.
    Auer G, Askensten U, Zetterberg A (1989) Microspectrophotometric nuclear DNA analysis in clinical tumor material. In: Baak JP (ed) Manual of quantitative pathology in cancer diagnosis. Springer, Berlin Heidelberg New York (in press)Google Scholar
  3. 3.
    Batsakis JG, Chinn EK, Weimert TA, Work WP, Krause CJ (1979) Acinic cell carcinoma: a clinicopathologic study of 35 cases. J Laryngol Otol 93:325–340Google Scholar
  4. 4.
    Bhaskar SN, Bernier JL (1962) Mucoepidermoid tumors of major and minor salivary glands. Cancer 15:801–817Google Scholar
  5. 5.
    Buxton RW, Maxwell JH, French AJ (1953) Surgical treatment of epithelial tumors of the parotid gland. Surg Gynecol Obstet 97:401–416Google Scholar
  6. 6.
    Caspersson T, Auer G, Fallenius A, Kudynowski J (1983) Cytochemical changes in the nucleus during tumor development. Histochem J 15:337–362Google Scholar
  7. 7.
    Chilla R, Casjens R, Eysholdt U, Droese M (1983) Maligne Speicheldrüsentumoren: Der Einfluß von Histologie und Lokalisation auf die Prognose. HNO 31:286–290Google Scholar
  8. 8.
    Corridan M (1956) Glycogen-rich clear cell adenoma of the parotid gland. J Pathol Bacteriol 72:623–628Google Scholar
  9. 9.
    Dietel M, Bodecker R, Arps H, Bahnsen J, Hölzel F (1985) Borderline-Tumoren des Ovars. Geburtshilfe Frauenheilkd 45:213–219Google Scholar
  10. 10.
    Ellis GL, Corio RL (1983) Acinic cell adenocarcinoma: a clinicopathologic analysis of 294 cases. Cancer 32:542–549Google Scholar
  11. 11.
    Eneroth CM, Zetterberg A (1973) Nuclear DNA content as a criterion of malignancy in salivary gland tumors of the oral cavity. Acta Otolaryngol (Stockh) 75:296–298Google Scholar
  12. 12.
    Eneroth CM, Zetterberg A (1974) Microspectrophotometric DNA analysis of malignant salivary gland tumors. Acta Otolaryngol (Stockh) 77:289–294Google Scholar
  13. 13.
    Eneroth CM, Zetterberg A (1975) The relationship between the nuclear DNA content in smears of aspirates and the prognosis of mucoepidermoid carcinoma. Acta Otolaryngol (Stockh) 80:429–433Google Scholar
  14. 14.
    Eneroth CM, Hamberger CA, Jakobsson PA (1966) Malignancy of acinic cell carcinoma. Ann Otol 75:780–792Google Scholar
  15. 15.
    Eneroth CM, Silfverswärd C, Zetterberg A (1974) Malignancy of acinic cell tumors elucidated by microspectrophotometric DNA analysis. Acta Otolaryngol (Stockh) 77:126–130Google Scholar
  16. 16.
    Evans HL (1984) Mucoepidermoid carcinoma of salivary glands: a study of 69 cases with special attention to histologic grading. Am J Clin Pathol 81:696–701Google Scholar
  17. 17.
    Ferlito A (1980) Acinic cell carcinoma of minor salivary glands. Histopathology 4:331–343Google Scholar
  18. 18.
    Gustafsson H, Lindholm C, Carlsöö B (1987) DNA cytophotometry of acinic cell carcinoma and its relation to prognosis. Acta Otolaryngol (Stockh) 104:370–376Google Scholar
  19. 19.
    Healey WV, Perzin KH, Smith L (1970) Mucoepidermoid carcinoma of salivary gland origin. Classification, clinicalpathologic correlation, and results of treatment. Cancer 26:368–388Google Scholar
  20. 20.
    Jakobsson PA, Blanck C, Eneroth CM (1968) Mucoepidermoid carcinoma of the parotid gland. Cancer 22:111–125Google Scholar
  21. 21.
    Kino I, Richart RM, Lattes R (1973) Nuclear DNA in salivary gland tumors. I. Warthin tumors, benign mixed tumors, and mucoepidermoid carcinomas. Arch Pathol 95:245–251Google Scholar
  22. 22.
    Kino I, Richart RM, Lattes R (1973) Nuclear DNA in salivary gland tumors. II. Adenocystic carcinoma. Arch Pathol 95:325–329Google Scholar
  23. 23.
    Laudadio P, Caliceti U, Cerasoli PT, Ceroni AR (1987) Mucoepidermoid tumour of the parotid gland: a very difficult prognostic evaluation. Clin Otolaryngol 12:177–182Google Scholar
  24. 24.
    Perzin KH, Livolsi VA (1979) Acinic cell carcinomas arising in salivary glands. Cancer 44:1434–1457Google Scholar
  25. 25.
    Sandritter W, Carl M, Ritter W (1966) Cytophotometric measurement of the DNA content of human malignant tumors by means of the feulgen reaction. Acta Cytol 10:26–30Google Scholar
  26. 26.
    Seifert G, Miehlke A, Haubrich J, Chilla R (1986) Diseases of the salivary glands. Thieme, StuttgartGoogle Scholar
  27. 27.
    Spiro RH, Huvos AG, Berk R, Strong EW (1978) Mucoepidermoid carcinoma of salivary gland origin. A clinicopathologic study of 367 cases. Am J Surg 136:461–468Google Scholar
  28. 28.
    Spiro RH, Huvos AG, Strong EW (1978) Acinic cell carcinoma of salivary origin. A clinicopathologic study of 67 cases. Cancer 41:924–935Google Scholar
  29. 29.
    Stewart FW, Foote FW, Becker WF (1945) Mucoepidermoid tumors of salivary glands. Ann Surg 122:820–844Google Scholar
  30. 30.
    Thackray AC, Lucas RB (1974) Tumors of the major salivary glands. Atlas of tumor pathology, second series, fascicle 10. Armed Forces Institute of Pathology, Washington, DCGoogle Scholar
  31. 31.
    Thackray AC, Sobin LH (1972) Histological typing of salivary gland tumours. World Health Organization, GenevaGoogle Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • K. Hamper
    • 1
  • J. Caselitz
    • 1
  • H. Arps
    • 1
  • U. Askensten
    • 2
  • G. Auer
    • 2
  • G. Seifert
    • 1
  1. 1.Institute of PathologyUniversity of HamburgHamburg 20Federal Republic of Germany
  2. 2.Department of PathologyKarolinska Institute and HospitalStockholmSweden

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