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Archives of oto-rhino-laryngology

, Volume 246, Issue 5, pp 328–332 | Cite as

The relationship between nuclear DNA content in salivary gland tumors and prognosis

Comparison of mucoepidermoid tumors and acinic cell tumors
  • K. Hamper
  • J. Caselitz
  • H. Arps
  • U. Askensten
  • G. Auer
  • G. Seifert
Head and Neck Surgery

Summary

Differences in prognosis between salivary gland mucoepidermoid tumors and acinic cell tumors were compared by means of conventional histopathological grading and nuclear DNA content which was assessed cytochemically by a scanning cytophotometric procedure. The mucoepidermoid tumors were found to show a stronger correlation between histopathological grading and prognosis than did the acinic cell tumors. By using DNA quantification, valuable additional information could be obtained for predicting the behavior of the mucoepidermoid tumors, whereas there was no correlation between DNA content and prognosis for the acinic cell tumors. Regarding the relatively “benign” clinical course of most mucoepidermoid tumors, the term “tumor” — as proposed by the World Health Organization's classification — seems appropriate. In contrast, the more severe clinical courses of the acinic cell tumors justify the use of the term “carcinoma” instead.

Key words

Salivary gland tumors DNA assessment Prognosis Acinic cell tumor Mucoepidermoid tumor 

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • K. Hamper
    • 1
  • J. Caselitz
    • 1
  • H. Arps
    • 1
  • U. Askensten
    • 2
  • G. Auer
    • 2
  • G. Seifert
    • 1
  1. 1.Institute of PathologyUniversity of HamburgHamburg 20Federal Republic of Germany
  2. 2.Department of PathologyKarolinska Institute and HospitalStockholmSweden

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