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The relationship between antigen levels and middle ear inflammation in antigen-induced otitis media in the chinchilla

Archives of oto-rhino-laryngology volume 245, pages 42–46 (1988)Cite this article

Summary

The relationship between antigen levels in middle ear effusions (MEE) and the degree of middle ear inflammation was studied in an antigen-induced otitis media model, using chinchillas sensitized with human serum albumin (HSA). The degree of middle ear inflammation was evaluated by both tympanometric analysis, and cytological and biochemical analyses of the MEE. Middle ear inflammation develops after HSA challenge with a remarkable decrease in HSA levels in the MEE. This inflammation persists even when HSA levels are no longer detectable in the MEE. These findings show that local challenges with an antigen induce a certain degree of middle ear inflammation, which continues even after complete elimination of the antigen from the middle ear through an immunological defense mechanism.

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Affiliations

  1. Department of Otolaryngology, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA

    F. Hamaguchi, Y. Hamaguchi & S. K. Juhn

  2. Department of Otorhinolaryngology, Mie University School of Medicine, Edobashi, Tsu, 2-174, Mie, 514, Japan

    Y. Sakakura

Authors
  1. F. Hamaguchi
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  2. Y. Hamaguchi
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  3. S. K. Juhn
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  4. Y. Sakakura
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Additional information

This research was supported by NINCDS grant NS-14538 for the Otitis Media Pathogenesis Research Program

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Hamaguchi, F., Hamaguchi, Y., Juhn, S.K. et al. The relationship between antigen levels and middle ear inflammation in antigen-induced otitis media in the chinchilla. Arch Otorhinolaryngol 245, 42–46 (1988). https://doi.org/10.1007/BF00463547

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  • DOI: https://doi.org/10.1007/BF00463547

Key words

  • Antigen-induced otitis media
  • Human serum albumin
  • Middle ear effusion