Archives of oto-rhino-laryngology

, Volume 206, Issue 4, pp 337–343 | Cite as

Influence of X-irradiation on the different stages of the cell cycle in regenerating rat liver

  • Hervé Barbason


Five groups of rats are partially hepatectomized in the afternoon. The first is the non-irradiated control and the others are irradiated (450R) at different post-operative delays of 1 h (hepatocytes in G0), 12 h (middle of G1), 20 h (end of G1 -beginning of S) and 28 h (S phase).

When the irradiation is performed in G0 or in G1 the same inhibition of mitotic waves, micronuclei and anatelophasic bridges index, is observed. However, the mitotic delay induced by the irradiation in G0 is completely reduced when the rats are irradiated after the middle of G1 (from the 12th post-operative hour).

When the irradiation is performed in the S phase, the first mitotic wave is almost completely inhibited. On the contrary, the second mitotic wave is the same as in the other irradiated groups and the micronuclei and the bridges appear at its level.

The results are discussed in the light of a possible relationship between the radiosensitivity and the different phases of the cell cycle.


Public Health Cell Cycle Irradiate Group Mitotic Delay Mitotic Wave 
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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • Hervé Barbason
    • 1
  1. 1.Laboratoire d'Anatomie PathologiqueUniversité de LiègeBelgien

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