Summary
We used transmission electron microscopy to examine the cochleae of non-obese diabetic mice as animal models for human type I or non-insulin-dependent diabetes mellitus. Pathological changes were observed in the organ of Corti of the basal turn and in the stria vascularis of each turn. Major findings in the stria vascularis were protrusion or condensation of marginal cells, swelling of intermediate cells, and widening of the intercellular spaces. Principal findings in the organ of Corti involved degenerative changes of the outer and inner hair cells and replacement of hair cells by supporting cells. No prominent pathological changes were observed in the capillaries. The possible mechanism of diabetic involvement in cochlear pathology is discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Axelsson A, Fagerberg S-E (1968) Auditory dysfunction in diabetes. Acta Otolaryngol (Stockh) 66:49–64
Axelsson A, Sigroth K, Vertes D (1978) Hearing in diabetes. Acta Otolaryngol [Suppl] (Stockh) 356:2–23
Bassiouny AR, Rosenberg H, McDonald JL (1983) Glyco-sylated collagen is antigenic. Diabetes 32:1182–1184
Bischoff A (1980) Morphology of diabetic neuropathy. Horm Metab Res [Suppl] 9:18–28
Cambell MJA (1971) A light and electron microscopic study of blood vessels from the gingival tissues of non-diabetic and diabetic patient. Aust Dent J 16:235–239
Cogan DG, Kawabara TK (1967) Ocular microangiopathy in diabetes. In: Kimura S, Caygill WM (eds) Vascular complications of diabetes mellitus. CV Mosby, St. Louis, pp 53–67
Fenton BM, Zweifach BW, Worthen DM (1978) Quantitative morphometry of conjunctival microcirculation in diabetes mellitus. Microvasc Res 18:153–166
Friedman SA, Schulma RH, Weiss S (1975) Hearing and diabetic neuropathy. Arch Intern Med 135:573–576
Gepts W (1965) Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14:619–633
Giacomelli F, Wiener J (1979) Primary myocardial disease in the diabetic mouse. Lab Invest 40:460–467
Gladney JH (1978) Experimental diabetes and the inner ear. A proposed biological model. Ann Otol Rhinol Laryngol 87:128–134
Goto Y, Ohyama T, Oikawa N, Sanoyama K, Toyota T, Mori K (1985) Etiological and precipitating factors of diabetic retinopathy. In: Sakamoto N, Min HK, Baba S (eds) Current topics in clinical and experimental aspects of diabetes mellitus. Elsevier, Amsterdam, pp 335–344
Harner SG (1981) Hearing in adult-onset diabetes mellitus. Otolaryngol Head Neck Surg 89:322–327
Kilo C, Vogler N, Williamson JR (1972) Muscle capillary basement membrane related to aging diabetes mellitus. Diabetes 21:884–905
Leuenberger P, Cambron S, Stauffacher W, Renold AE, Babel J (1971) Ocular lesions in rats rendered chronically diabetic with streptozotocin. Ophthalmol Res 2:189–204
Makino S, Kunimoto K, Muraoka Y, Mizushima Y, Katagiri K, Tochino Y (1980) Breeding of a non-obese, diabetic strain of mice. Exp Anim (Tokyo) 29:1–13
Makino S, Hayashi Y, Muraoka Y, Tochino Y (1985) Establishment of the nonobese-diabetic (NOD) mouse. In: Sakamoto N, Min HK, Baba S (eds) Current topics in clinical and experimental aspects of diabetes mellitus. Elsevier, Amsterdam, pp 25–31
Makishima K, Tanaka K (1971) Pathological changes of the inner ear and central auditory pathway in diabetic. Ann Otol Rhinol Laryngol 80:218–228
Marliss EB, Nakhooda AF, Paussier P, Sima AAF (1982) The diabetic syndrome of the ‘BB’ Wistar rat: possible relevance to type I (insulin-dependent) diabetes in man. Diabetologica 22:225–232
Marshak CT (1972) The inner ear in experimental diabetes mellitus. Acta Otolaryngol (Stockh) 300:1–18
Mauer SM, Steffes MW, Michael AF, Brown DM (1976) Studies of diabetic nephropathy in animals and man. Diabetes [Suppl 2] 25:850–875
Myers SF, Ross MD, Jokelainer P, Graham MD, McClatchey KD (1985) Morphological evidende of vestibular pathology in long-term experimental diabetes mellitus. Acta Otolaryngol (Stockh) 100:351–364
Naji A, Barker CF (1984) Animal models of human type I diabetes. In: Gupta S (ed) Immunology of clinical and experimental diabetes. Plenum, New York, pp 91–112
Østerby R (1975) Early phases in the development of diabetic glomerulopathy. A quantitative electron microscopic study. Acta Med Scand [Supp] 574:3–82
Robinson WG, Kador PF, Kinosita JH (1983) Retinal capillaries: basement membrane thickening by galactosemia prevented with aldose reductase inhibitor. Science 221: 1177–1179
Tachibana M, Nakae S (1986) The cochlea of the spontaneously diabetic mice. I. Electron microscopic observation of KK mice. Arch Otorhinolaryngol 243:238–241
Taylor IG, Irwin J (1978) Some audiological aspects of diabetes mellitus. J Laryngol Otol 92:99–113
Tochino Y, Kanaya T, Makino S (1982) Genetics of NOD mice. In: Mimura G, Baba S, Goto Y, Köbbering J (eds) Clinico-genetic genesis of diabetes mellitus. Excerpta Medica, Amsterdam, pp 285–291
Tomoda K, Yoo TJ (1983) Type II collagen distribution in the inner ear. In: Lim DJ (ed) Abstracts of the sixth midwinter research meeting of the Association for Research in Otolaryngology 36, Florida
Yodaiken RE, Seftel HC, Rubenstein AN (1967) Ultra-structure of dermal capillaries of Africans in South Africa. Diabetes 16:191–197
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nakae, S., Tachibana, M. The cochlea of the spontaneously diabetic mouse. Arch Otorhinolaryngol 243, 313–316 (1986). https://doi.org/10.1007/BF00460208
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00460208