Zusammenfassung
Protein- und Amylasegehalt sowie die Verteilung der Isoamylasen wurden in der Gl. parotis und in der Gl. submandibularis unter 3- bis 21tägiger Tolbutamidbehandlung bestimmt. Nur die Gl. submandibularis zeigte deutliche Veränderungen gegenüber den Kontrollen: eine deutliche Abnahme der Amylaseaktivität nach 3tägiger und eine Steigerung der Aktivität um das Siebenfache nach 21tägiger Behandlung. Eine vom Insulineffekt unabhängige Ausschüttung von Adrenalin aus dem Nebennierenmark und die mögliche Hemmung einer am Proteinsekretionsprozeß der Gl. submandibularis beteiligten Proteinkinase könnte diese Befunde erklären.
Summary
Protein and amylase content as well as the distribution of isoamylases were determined in the parotid and the submandibular glands of the rat following treatment with tolbutamide for 3–21 days. Significant changes were only observed in the submandibular glands in which, compared with the controls, the amylase activity decreased distinctly after 3 days but had increased 7-fold after 21 days of tolbutamide. These findings could be explained by secretion of epinephrine from the adrenal medulla supposed to take place independently of the effect of insulin and by the possible inhibition of a protein kinase involved in the process of protein secretion from the submandibular gland.
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Chilla, R., Schwarztrauber, W. & Arglebe, C. Effects of tolbutamide on the protein secretion of the rat salivary glands. Arch Otorhinolaryngol 232, 221–226 (1981). https://doi.org/10.1007/BF00457445
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DOI: https://doi.org/10.1007/BF00457445