Zusammenfassung
Kanamycin in einer Dosis von 400 mg/kg täglich über 5 Tage bewirkt eine deutliche Empfindlichkeitssteigerung für audiogene Anfälle bei BALB/c-Mäusen, wenn das Medikament zwischen 10. und 14. postnatalem Tag verabreicht wird. Kanamycin in gleicher Dosis hat aber keinen Effekt, wenn es zwischen 5.–9., 15.–19. oder 20.–24. postnatalem Tag gegeben wird. Da die Erhöhung der Anfälligkeit für audiogene Anfälle einen deutlichen Zusammenhang mit dem Grad von Cochleaschaden durch ototoxische Medikamente oder Lärm hat, wird angenommen, daß der 10.–14. postnatale Tag die empfindlichste Periode für den ototoxischen Effekt des Kanamycins darstellt.
Summary
It has been found that administration of kanamycin (400 mg/kg daily) for 5 days was highly effective in inducing susceptibility to audiogenic seizures in BALB/c mice, if the drug was administered between the age of 10–14 postnatal days. The same drug dosage administered between the age of 5–9, 15–19, or 20–24 postnatal days was found to be ineffective. Since induction of seizure susceptibility is highly correlated with the degree of cochlear damage produced by either ototoxic drugs or noise, it was suggested that the age of 10–14 postnatal days could be the most sensitive period for the ototoxic effect of kanamycin.
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Supported by grants from the Australian Research Grants Committee
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Chen, C.S., Aberdeen, G.C. The sensitive period for induction of susceptibility to audiogenic seizures by kanamycin in mice. Arch Otorhinolaryngol 232, 215–220 (1981). https://doi.org/10.1007/BF00457444
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DOI: https://doi.org/10.1007/BF00457444