Archives of Dermatological Research

, Volume 280, Issue 3, pp 182–184 | Cite as

Effects of protein kinase C activators on mouse skin in vivo

  • S. Inohara
  • H. Tateishi
  • Y. Takeda
  • Y. Tanaka
  • S. Sagami
Short Communications

Key words

TPA OAG Protein kinase C Mouse skin 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Ashendel CL (1985) The phorbol ester receptor; a phospholipid-regulated protein kinase. Biochim Biophys Acta 822:219–242Google Scholar
  2. 2.
    Brockenbrough JS, Korc M (1987) Effects of 1-oleoyl-2-acetyl-glycerol are distinct from those of phorbol ester in rat pancreatic acini. Life Sci 40:1625–1631Google Scholar
  3. 3.
    Castagna M, Takai Y, Kaibuchi K, Sano K, Kikkawa U, Nishizuka Y (1982) Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J Biol Chem 257:7847–7851Google Scholar
  4. 4.
    Kaibuchi K, Takai Y, Sawamura M, Hoshijima M, Fujikura T, Nishizuka Y (1983) Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation. J Biol Chem 258:693–697Google Scholar
  5. 5.
    Kikkawa U, Takai Y, Tanaka K, Miyake R, Nishizuka Y (1983) Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters. J Biol Chem 258:11442–11445Google Scholar
  6. 6.
    Kikkawa U, Ono Y, Ogita K, Fujii T, Asaoka Y, Sekiguchi K, Kosaka Y, Igarashi K, Nishizuka Y (1987) Identification of the structure of multiple subspecies of protein kinase C expressed in rat brain. FEBS Lett 217:227–231Google Scholar
  7. 7.
    Kvedar J, Levine L (1987) Modulation of arachidonic acid metabolism in a cultured newborn rat keratinocyte cell line. J Invest Dermatol 88:124–129Google Scholar
  8. 8.
    Niedel JE, Kuhn LJ, Vandenbark GR (1983) Phorbol diester receptor copurifies with protein kinase C. Proc Natl Acad Sci USA 80:36–40Google Scholar
  9. 9.
    Nishizuka Y (1984) The role of protein kinase C in cell surface signal transduction and tumor promotion. Nature 381:693–697Google Scholar
  10. 10.
    Ogawa H, Hattori M (1983) Regulation mechanism of hair growth. In: Seiji M, Bernstein IA (eds) Normal and abnormal epidermal differentiation. University of Tokyo Press, Tokyo, pp 159–170Google Scholar
  11. 11.
    Raick AN, Thumm K, Chivers BR (1972) Early effects of 12-O-tetradecanoyl-phorbol-13-acetate on the incorporation of tritiated precursors into DNA, and the thickness of interfollicular epidermis, and their relation to tumor promotion in mouse skin. Cancer Res 32:1562–1568Google Scholar
  12. 12.
    Sasakawa N, Ishii K, Yamamoto S, Kato R (1985) Induction of ornithine decarboxylase activity by 1-oleoyl-2-acetylglycerol in isolated mouse epidermal cells. Biochem Biophys Res Commun 128:913–920Google Scholar
  13. 13.
    Yamamoto S, Gotoh H, Aizu E, Kato R (1985) Failure of 1-oleoyl-2-acetylglycerol to mimic the cell-differentiating action of 12-O-tetradecanoylphorbol-13-acetate in HL-60 cells. J Biol Chem 260:14230–14234Google Scholar
  14. 14.
    Yuspa SH (1984) Tumor promotion in epidermal cells in culture. In: Slaga TJ (ed) Mechanism of tumor promotion, vol 3. CRC press, Boca Raton, Florida, pp 1–11Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • S. Inohara
    • 1
  • H. Tateishi
    • 1
  • Y. Takeda
    • 1
  • Y. Tanaka
    • 1
  • S. Sagami
    • 1
  1. 1.Department of DermatologyHyogo College of MedicineHyogoJapan

Personalised recommendations