Archives of Dermatological Research

, Volume 280, Issue 3, pp 140–144 | Cite as

Collagen-type synthesis in human-hair papilla cells in culture

  • K. Katsuoka
  • C. Mauch
  • H. Schell
  • O. P. Hornstein
  • Th. Krieg
Original Contributions

Summary

Hair-papilla derived cells were grown in monolayer culture and revealed the typical morphology and growth pattern which was similar but not identical to control fibroblasts. Hair-papilla cells were found to produce considerable amounts of collagen type I and type III and fibronectin. Type IV collagen production could not be detected. The ratio of collagen type III and type I clearly differed from the pattern observed in normal fibroblasts, being much higher in hair-papilla cells, where type III accounted for more than 20% of total collagen synthesis. These data show that hair-papilla derived cells have biosynthetic capacities similar to those of human skin fibroblasts as well as characteristic differences, indicating that they represent a specialized fibroblast subpopulation.

Key words

Hair papilla cells Cell culture Collagen synthesis 

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • K. Katsuoka
    • 2
  • C. Mauch
    • 1
  • H. Schell
    • 2
  • O. P. Hornstein
    • 2
  • Th. Krieg
    • 1
  1. 1.Dermatologische Klinik und Poliklinik der Ludwig-Maximilians-Universität MünchenMünchen 2Germany
  2. 2.Dermatologische Klinik der Universität Erlangen-NürnbergErlangenGermany

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