The temporal bones from 18 deaf Dalmatian dogs were examined with the light microscope, and the cochleo-saccular degeneration process studied. End organ degeneration is already advanced by the age of 4 weeks, whilst loss of neurons in the spiral ganglion was found only in adult animals. Both processes are first evident in the central portion of the cochlea, and increase in extent with advancing age. The implications of these findings for the management of non-conductive hearing loss in man are discussed.
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The author would like to express his appreciation and gratitude for the assistance and advice he has received from Dr. C. Fernandez, University of Chicago, Chicago, Illinois.
This study was supported in part by Grant NB-0682 from the National Institute of Health, Washington, and by Grant C.27. 14-2 from the Norwegian Research Council for Science and the Humanities.
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Mair, I.W.S. Hereditary deafness in the Dalmatian dog. Arch Otorhinolaryngol 212, 1–14 (1976). https://doi.org/10.1007/BF00456358
- Hereditary deafness
- Dalmatian dogs
- Cochleo-saccular degeneration
- Spiral ganglion degeneration