Spermatogonial stem cell renewal in the rat, mouse and golden hamster

A study with the alkylating agent Myleran
  • D. G. de Rooij
  • M. P. Kramer


With the help of the alkylating agent Myleran we confirmed our finiding that in the rat, mouse and golden hamster the spermatogonial stem cells are daughter cells of the last generation of A spermatogonia.


Stem Cell Daughter Cell Alkylating Agent Golden Hamster Spermatogonial Stem Cell 
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  1. Amann, R. P.: Reproductive capacity of dairy bulls. IV Spermatogenesis and testicular germ cell degeneration. Amer. J. Anat. 110, 69–78 (1962).Google Scholar
  2. Clermont, Y.: Cycle de l'épithélium séminal et mode de renouvellement des spermatogonies chez le hamster. Rev. Canad. Biol. 13, 208–245 (1954).Google Scholar
  3. —: Quantitative analysis of spermatogenesis of the rat: A revised model for the renewal of spermatogonia. Amer. J. Anat. 111, 111–129 (1962).Google Scholar
  4. —, and E. Bustos-Obregon: Re-examination of spermatogonial renewal in the rat by means of seminiferous tubules mounted “in toto”. Amer. J. Anat. 122, 237–248 (1968).Google Scholar
  5. —, and S. C. Harvey: Duration of the cycle of the seminiferous epithelium of normal, hypophysectomized and hypophysectomized-hormone treated albino rats. Endocrinology 76, 80–89 (1965).Google Scholar
  6. Gowin, R. L. de: Erythroid differentiation during stem cell proliferation. J. Lab. clin. Med. 70, 23–35 (1967).Google Scholar
  7. Hilscher, B., W. Hilscher, and W. Maurer: Autoradiographische Bestimmung der Generationszeiten und Teilphasen der verschiedenen Spermatogonien-Generationen der Ratte. Naturwissenschaften 16, 415–416 (1966).Google Scholar
  8. Hilscher, W., and H.B. Makoski: Histologische und autoradiographische Untersuchungen zur „Präspermatogenese“ und „Spermatogenese“ der Ratte. Z. Zellforsch. 86, 327–350 (1968).Google Scholar
  9. Jackson, H., B. W. Fox, and A. W. Craig: Antifertility substances and their assessment in the male rodent. J. Reprod. Fertil. 2, 447–465 (1961).Google Scholar
  10. Kramer, M. F., A. de Lange, and M. B. H. Visser: Spermatogonia of the bull. Z. Zellforsch. 63, 735–758 (1964).Google Scholar
  11. Lewis, J. P., and F. E. Trobaugh: Haematopoietic stem cells. Nature (Lond.) 204, 589–590 (1964).Google Scholar
  12. Oakberg, E. F.: A description of spermiogenesis in the mouse and its use in analysis of the cycle of the seminiferous epithelium and germ cell renewal. Amer. J. Anat. 99, 391–409 (1956).Google Scholar
  13. —: Duration of spermatogenesis in the mouse and timing of stages of the cycle of the seminiferous epithelium. Amer. J. Anat. 99, 507–516 (1956).Google Scholar
  14. Ortavant, R.: Spermatogenesis and morphology of the spermatozoon. In: Reproduction in domestic animals, vol. II (H. H. Cole and P. T. Cupps, eds.). New York: Academic Press 1959.Google Scholar
  15. Partington, M., B. W. Fox, and H. Jackson: Comparative action of some methane sulphonic esters on the cell population of the rat testis. Exp. Cell Res. 33, 78–88 (1964).Google Scholar
  16. Rooij, D. G. de.: Stem cell renewal and duration of spermatogonial cycle in the golden hamster. Z. Zellforsch. 89, 133–136 (1968).Google Scholar
  17. —, and M. F. Kramer: Spermatogonial stem cell renewal in rats and mice. Z. Zellforsch. 85, 206–209 (1968).Google Scholar
  18. - - Spermatogonial stem cell renewal in the rat, mouse and golden hamster. Proceedings of the VIth int. Congr. on Animal Reproduction and Artificial Insemination. In press (1968b).Google Scholar

Copyright information

© Springer-Verlag 1968

Authors and Affiliations

  • D. G. de Rooij
    • 1
  • M. P. Kramer
    • 1
  1. 1.Department of HistologyState University Medical School UtrechtThe Netherlands

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