Archives of oto-rhino-laryngology

, Volume 226, Issue 1–2, pp 101–105 | Cite as

Hypofibrinolysis in Menière's disease

Preliminary report
  • Axel Bomholt


Hypofibrinolysis was found in five patients with Menière's disease that all started with sudden hearing loss. A connection between hypofibrinolysis and Menière's disease is proposed. The possibility that the symptoms of Menière's disease and endolymphatic hydrops is due to an inner ear vascular disorder, is discussed. It is concluded that, if the hypothesis is correct, it can lead to a causal therapy in some cases of Menière's disease.

Key words

Sudden sensorineural hearing loss Menière's disease Hypofibrinolysis Hyperlipidemia 

Hypofibrinolyse bei Morbus Menière


Bei fünf Patienten mit M. Menière, bei denen die Erkrankung mit einem Hörsturz begann, wurde eine veränderte fibrinolytische Aktivität im Blutplasma festgestellt. Ein Zusammenhang zwischen der Hypofibrinolyse und der Menièreschen Erkrankung wird vermutet und die Möglichkeit diskutiert, daß Symptome und endolymphatischer Hydrops bei dieser Erkrankung Folge einer vaskulären Störung sind.


Hörsturz M. Menière Hypofibrinolyse 


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  1. Andersen, L. A., Gormsen, J.: Platelet aggregation and flbrinolytic activity in transient cerebral ischemia. Acta Neurol. Scand. 55, 76 (1976)Google Scholar
  2. Bomholt, A., Bak-Pedersen, K., Gormsen, J.: Fibrinolytic activity in patients with sudden sensorineural hearing loss. Acta Otolaryngol. [Suppl.] 360, 184 (1979)Google Scholar
  3. Enander, A., Stahle, J.: Hearing in Menière's disease. Acta Otolaryngol. 64, 543 (1967)Google Scholar
  4. Epstein, S. E., Rosing, D. S., Brokman, P., Redwood, D. R., Astruge, T.: Impaired fibrinolytic response to exercise in patients with type IV-hyperlipoproteinaemia. Lancet 1970 II, 631Google Scholar
  5. Hallberg, O. E.: Cochlear hydrops. In: Menière's disease. Pulac, J. (ed.), p. 479. Philadelphia: Saunders 1968Google Scholar
  6. Hallpike, C. S., Cairns, H.: Observations of the pathology of Menière's syndrom. J. Laryngol. Otol. 53, 625 (1938)Google Scholar
  7. Martinez, D.: Simultaneous measurement of endolymphatic and perilymphatic fluid pressures before and during anaphylaxis and associated changes in cerebrospinal fluid, venous and arterial pressures. Acta Otolaryngol. [Suppl.] 238 (1965)Google Scholar
  8. Nilsson, I. M.: Effect of drugs on activator synthesis and release. In: Progress in chemical fibrinolysis and thrombolysis, Vol. 3. Davidson, Y. F., Rowan, M. M., Samama, M. M., Desnoyer, C. C. (eds.), p. 77. New York: Raven Press 1978Google Scholar
  9. Perlman, H. B., Kimura, R.: Experimental obstruction of venous drainage and arterial supply of the inner ear. Ann. Otol. Rhinol. Laryngol. 66, 537 (1957)Google Scholar
  10. Schuknecht, H. F.: Pathology in Menière's disease. In: Menière's disease. Pulac, J. (ed.), p. 331. Philadelphia: Saunders 1968Google Scholar
  11. Spencer, J. T.: Hyperlipoproteinaemia in the etiology of inner ear disease. Laryngoscope 83, 639 (1975)Google Scholar
  12. Torok, N.: Old and new in Menière disease. Laryngoscope 87, 1870 (1977)Google Scholar
  13. Wolff, D., Bernhard, W. G., Tsutsumi, S., Ross, I. S., Nussbaum, H. E.: The pathology of Cogan's syndrom causing profound deafness. Ann. Otol. Rhinol. Laryngol. 74, 507 (1965)Google Scholar

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Axel Bomholt
    • 1
  1. 1.ENT-DepartmentUniversity Hospital, HvidovreCopenhagenDenmark

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