Summary
In a double blind trial adenine arabinoside (Vidarabine) and Idoxuridine (IDU) were tested in herpes simplex and herpes zoster infections. Adenine arabinoside covered 19 patients with HSV and 6 with HZ while IDU 19 with HSV and 6 with HZ. From the statistical analysis it was found that Vidarabine acts shorter than IDU in HSV P<0.01, while in HZ no significant difference P<0.5 was found, possibly due to the small number of patients tested.
Zusammenfassung
Unter doppeltem Blindversuch wurden Adenine-Arabinosid und Jodoxuridin bei Patienten mit Herpes simplex und Herpes zoster miteinander verglichen.
Adenin-Arabinosid kam bei 19 Patienten mit Herpes simplex und 6 Patienten mit Herpes zoster zur Anwendung, während Jodoxuridin bei 19 Patienten mit Herpes zoster und 6 Herpes simplex verglichen wurde. Nach statistischer Analyse wirkt Adenin-Arabinosid schneller als das Vergleichspräparat bei Herpes simplex, während beim Herpes zoster keine signifikanten Unterschiede gefunden wurden, wahrscheinlich wegen der kleinen Patientenzahl für diese Indikation.
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Theodoridis, A., Sivenas, C., Vagena, A. et al. Double blind trial in the treatment of herpes simplex and herpes zoster with adenine arabinoside and idoxuridine. Arch Dermatol Res 262, 173–176 (1978). https://doi.org/10.1007/BF00455387
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DOI: https://doi.org/10.1007/BF00455387