Archives of Dermatological Research

, Volume 262, Issue 2, pp 173–176 | Cite as

Double blind trial in the treatment of herpes simplex and herpes zoster with adenine arabinoside and idoxuridine

  • A. Theodoridis
  • C. Sivenas
  • A. Vagena
  • J. Capetanakis
Original Papers

Summary

In a double blind trial adenine arabinoside (Vidarabine) and Idoxuridine (IDU) were tested in herpes simplex and herpes zoster infections. Adenine arabinoside covered 19 patients with HSV and 6 with HZ while IDU 19 with HSV and 6 with HZ. From the statistical analysis it was found that Vidarabine acts shorter than IDU in HSV P<0.01, while in HZ no significant difference P<0.5 was found, possibly due to the small number of patients tested.

Key words

Antimetabolite Virus Vaccinia Antivirous activity Deaminase inhibitor 

Zusammenfassung

Unter doppeltem Blindversuch wurden Adenine-Arabinosid und Jodoxuridin bei Patienten mit Herpes simplex und Herpes zoster miteinander verglichen.

Adenin-Arabinosid kam bei 19 Patienten mit Herpes simplex und 6 Patienten mit Herpes zoster zur Anwendung, während Jodoxuridin bei 19 Patienten mit Herpes zoster und 6 Herpes simplex verglichen wurde. Nach statistischer Analyse wirkt Adenin-Arabinosid schneller als das Vergleichspräparat bei Herpes simplex, während beim Herpes zoster keine signifikanten Unterschiede gefunden wurden, wahrscheinlich wegen der kleinen Patientenzahl für diese Indikation.

Schlüsselwörter

Antimetabolit Virus Vaccina Antivirale Tätigkeit Deaminase Inhibitor 

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • A. Theodoridis
    • 1
  • C. Sivenas
    • 1
  • A. Vagena
    • 1
  • J. Capetanakis
    • 1
  1. 1.Department of Dermatology, “A. Sygros” HospitalUniversity of AthensAthensGreece

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