Plasma kinin activation in tranexamic acid treated patients with hereditary angioneurotic edema

Summary

Plasma kinin formation after in vitro activation of factor XII in the coagulation system was examined in 4 patients with hereditary angioneurotic edema. Compared to controls activationcurves showed a steeper increase and higher maximum levels. Administration of tranexamic acid to the patients resulted in partial normalisation of plasma kinin activation.

Zusammenfassung

Die Plasmakininbildung nach in vitro-Aktivation des Faktors XII im Gerinnungssystem wurde bei 4 Patienten mit hereditärem angioneurotischem Ödem untersucht. Verglichen mit den Kontrollen, zeigten die Aktivkurven einen steileren Anstieg und einen höheren maximalen Spiegel. Die Verabreichung von Tranexansäure, eine der Epsilonaminocapronsäure analoge Verbindung, fürhrte zur teilweisen Normalisation der Plasmakininaktivierung.

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Lauerberg, G. Plasma kinin activation in tranexamic acid treated patients with hereditary angioneurotic edema. Arch Dermatol Res 262, 153–156 (1978). https://doi.org/10.1007/BF00455384

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Key words

  • Kinin, Factor XII
  • Tranexamic acid
  • Hereditary angioneurotic edema

Schlüsselwörter

  • Kinine, Faktor XII
  • Tranexansäure
  • Hereditäres angioneurotisches Ödem