Summary
Time course and dose-response relationships have been studied for medium-wave ultraviolet radiation (UVB) in the mouse by measuring the inflammatory oedema of tail tissue. The time course was shown to be dose dependent, larger doses peaking earlier than smaller ones. For intermediate doses the reaction culminated after 48 h. Dose-response curves were sigmoid-shaped with good linear correlation in the region of maximal slope. The dose-response curve was studied at varying intervals after irradiation and the relationship could be shown to be time dependent. UVB differs in some of these respects from phototoxic reactions to chlorpromazine and 8-methoxypsoralen.
Zusammenfassung
Zeitverlauf und Dosis-Wirkungs-Verhältnisse (dose-response) für Ultraviolettentzündung hervorgerufen durch mittelwellige Strahlung (UVB) wurden an Mäusen untersucht. Die angewandte Methode gründet sich auf Messung der entzündlichen Schwellung des Schwanzgewebes. Mit mittleren UVB-Dosen wurden maximale Werte nach 48 h erreicht. Der Zeitverlauf war dosisabhängig: größere Dosen hatten ein früheres Maximum als kleinere. Dosis-Wirkungs-Kurven hatten im steilsten Abschnitt gute lineare Korrelation. Kurven wurden nach unterschiedlichen Intervallen studiert und ihre Form erwies sich als zeitabhängig. UVB unterscheidet sich hier in gewisser Hinsicht von phototoxischen Reaktionen mit Chlorpromazin und 8-Methoxypsoralen.
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This work was supported by grants from the Edward Welander and the Alfred Österlund Foundations
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Ljunggren, B. Dynamics of ultraviolet dermatitis as studied with the mouse tail technique. Arch Dermatol Res 261, 1–6 (1978). https://doi.org/10.1007/BF00455369
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DOI: https://doi.org/10.1007/BF00455369