Summary
Postganglionic sweat output in ten patients with atopic dermatitis was determined by a quantitative sudomotor axon reflex test in which the output results from axon reflex stimulation by acetylcholine iontophoresis. All measurements were obtained from normal skin on the volar aspect of the left wrist and dorsal aspect of the left foot of the atopic patients. Latency, sweat volume, and dynamic sweat pattern were variables included in the study. An abnormal value or configuration was found in nine of the ten patients studied. Seven of the ten patients had abnormal sweat output values. Atopic patients have abnormal sweating patterns, which may be inherently responsible for or related to their disorder.
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Cotton DWK, Van Rossum E (1973) Hexokinase, glucose-6-phosphate dehydrogenase, and malate dehydrogenase in the isolated sweat glands of normal and atopic subjects. Br J Dermatol 89:459–465
Förström L, Goldyne ME, Winkelmann RK (1975) IgE in human eccrine sweat. J Invest Dermatol 64:156–157
Foster KG, Haspineall JR, Mollel CL (1971) Effects of propranolol on the response of human eccrine sweat glands to acetolcholine. Br J Dermatol 85:363–367
Gordon BI, Maibach HI (1966) Studies of acetylcholine-and methacholine-induced sweating. Arch Dermatol 94: 778–781
Hemels HGWM (1970) The effect of propranolol on the acetylcholine-induced sweat gland response in atopic and non-atopic subjects. Br J Dermatol 83:312–314
Korting GW (1954) Zur Pathogenese des endogenen Ekzems. Thieme, Stuttgart
Lobitz WC Jr, Campbell CJ (1953) Physiologic studies in atopic dermatitis (disseminated neurodermatitis). I. The local cutaneous response to intradermally injected acetylcholine and epinephrine. Arch Dermatol Syphilology 67: 575–589
Low PA, Caskey PE, Tuck RR, Fealey RD, Dyck PJ (1983) Quantitative sudomotor axon reflex test in normal and neuropathic subjects. Ann Neurol 14:573–580
Murphy GM, Smith SE, Smith SA, Greaves MW (1984) Autonomic function in cholinergic urticaria and atopic eczema. Br J Dermatol 110:581–586
Rovensky J, Saxl O (1964) Differences in the dynamics of sweat secretion in atopic children. J Invest Dermatol 43:171–176
Sato K, Sato F (1983) Individual variations in structure and function of human eccrine sweat gland. Am J Physiol 245:R203-R208
Seutter E, Goedhart-de Groot N, Sutorius AHM, Urselmann EJM (1970) The quantitative analysis of some constituents of crude sweat. Dermatologica 141:226–233
Sulzberger MB, Herrmann F, Borota A, Strauss MB (1953) Studies of sweating. VI. On the urticariogenic properties of human sweat. J Invest Dermatol 21:293–303
Sulzberger MB, Herrmann F, Morrill SD, Pascher F, Miller K (1959) Studies of sweat, lipids, and histopathology in children with “dry skin” (xerosis). Int Arch Allergy Appl Immunol 14:129–143
Szentivanyi A (1968) The beta-adrenergic theory of the atopic abnormality in bronchial asthma. J Allergy 42:203–232
Warndorff JA (1970) The response of the sweat gland to acetylcholine in atopic subjects. Br. J Dermatol 83:306–311
Warndorff JA, Hamer M (1974) The response of the sweat glands to beta-adrenergic stimulation with isoprenaline. Br J Dermatol 90:263–268
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Greene, R.M., Winkelmann, R.K., Opfer-Gehrking, T.L. et al. Sweating patterns in atopic dermatitis patients. Arch Dermatol Res 281, 373–376 (1989). https://doi.org/10.1007/BF00455319
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DOI: https://doi.org/10.1007/BF00455319