Summary
Twenty-three biopsies of skin lesions of patients with various types of leprosy, showing a recent reaction, were examined by means of immunofluorescence (IF) methods. The patients were divided into two groups according to the number of inflammatory cells, staining with various FTC-labelled antiimmunoglobulin antisera, in representative areas of the biopsies.
It was found that the presence of these cells was correlated with a good response to thalidomide treatment.
Zusammenfassung
Dreiundzwanzig Hautbiopsien von Patienten mit verschiedenen Lepraformen, die eine rezente Reaktion zeigten, wurden mittels der Immunofluorescenz (IF)-Technik untersucht. Die Patienten konnten in zwei Gruppen verteilt werden, abhängig von der Zahl der Entzündungszellen in repräsentativen Biopsiegebiete, die fluorescierenden mit FTC-gekoppelte Anti-Immunoglobulin-Antisera.
Es zeigte sich eine positive Korrelation dieser Zellen bei einer erfolgreichen Thalidomidbehandlung.
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Faber, W.R., Leiker, D.L. & Cormane, R.H. Immunofluorescence studies in reactional leprosy with relevance to treatment. Arch Dermatol Res 261, 323–330 (1978). https://doi.org/10.1007/BF00455302
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DOI: https://doi.org/10.1007/BF00455302