Archives of oto-rhino-laryngology

, Volume 225, Issue 3, pp 207–209 | Cite as

Prostaglandins in experimental otitis media

  • Douglas M. Smith
  • Timothy T. K. Jung
  • S. K. Juhn
  • Norman T. Berlinger
  • Jonathan M. Gerrard
Article

Summary

Levels of prostaglandins in serum, plasma and middle ear effusions (MEE) in chinchilla were measured by radioimmunoassay. Higher levels of PGE2 and PGF were observed in the POM group than in the SOM group. Prostaglandins appear to play important roles as a mediator of the inflammatory response in experimentally induced purulent otitis media.

Key words

Otitis media Prostaglandins Inflammatory mediators 

Prostaglandine bei experimenteller Otitis media

Zusammenfassung

Die Prostaglandinwerte im Serum, Plasma und Mittelohrerguß werden beim Chinchilla mittels Radioimmuntest bestimmt. Es zeigt sich, daß Prostaglandine wahrscheinlich eine wichtige Mittlerrolle bei Entstehung einer experimentellen eitrigen Mittelohrentzündung spielen.

Schlüsselwörter

Mittelohrentzündung Prostaglandine Entzündliche Mittlerrolle 

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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • Douglas M. Smith
    • 1
  • Timothy T. K. Jung
    • 1
  • S. K. Juhn
    • 1
  • Norman T. Berlinger
    • 1
  • Jonathan M. Gerrard
    • 1
  1. 1.Department of Otolaryngology and Pediatrics, Medical SchoolUniversity of MinnesotaMinneapolisUSA

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