Zusammenfassung
Die zyklischen Nukleotide Adenosin (cAMP) und Guanosin (cGMP) sind im Speichel der menschlichen Parotis reichlich nachzuweisen. Nach Stimulation mit Zitronensäure vermindert sich die Konzentration der zyklischen Nukleotide im Speichel, während die Sekretionsrate zunimmt. Während des Essens sind sowohl Konzentration als auch Sekretion an cAMP vermehrt. Parotisspeichel bei Sjögren-Syndrom zeigt eine höhere cGMP-Konzentration als bei Normalpersonen. Bei malignen Parotistumoren ist die cGMP-Konzentration höher und die cAMP-Konzentration niedriger als bei Gesunden.
Summary
Human parotid saliva was revealed to contain considerable amounts of cAMP and cGMP. On sour lemon drop stimulation, the salivary cyclic nucleotides concentration decreased and the cyclic nucleotides secretory rate increased in close relationship with the salivary flow rate in control subjects. On feeding, both cAMP concentration and secretory rate increased significantly in control subjects. Parotid saliva from a patient of Sjögren's syndrom was revealed to have a significantly higher cGMP concentration than those from control subjects. Saliva derived from the malignant tumor of the parotid gland was revealed to have a higher cGMP concentration and a lower cAMP concentration than the healthy site. From these findings, the possibilities of the clinical usefulness of studying salivary cyclic nucleotides were discussed.
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Asakura, K., Kataura, A. cAMP and cGMP in the human parotid saliva. Arch Otorhinolaryngol 226, 145–154 (1980). https://doi.org/10.1007/BF00455129
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DOI: https://doi.org/10.1007/BF00455129