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Malignant mixed tumor of the lacrimal gland

A clinicopathologic report of two unusual cases

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Abstract

Two cases of malignant transformation in an originally benign mixed tumor of the lacrimal gland (pleomorphic adenoma) are presented. In both patients the unusual histopathologic appearance of the malignant component gave rise to considerable problems in clinical and histopathologic diagnosis. In one case the malignant tumor had a sarcomatous appearance, while in the other there was sebaceous differentiation mimicking an adenocarcinoma of the Meibomian glands.

Zusammenfassung

Zwei Fälle von maligner Umwandlung in einem ursprünglich gutartigen Mischtumor der Tränendrüse (pleomorphes Adenom) werden vorgestellt.

In beiden Fällen gab das ungewöhnliche histo-pathologische Erscheinungsbild der malignen Komponente des Tumors Anlaß zu erheblichen Problemen in der klinischen und histo-pathologischen Diagnose. In einem Falle hatte der bösartige Tumor ein sarkomatöses Aussehen, während er in dem anderen Falle eine Talgdrüsen-ähnliche Differenzierung zeigte und auf diese Weise ein Adenokarzinom der Meibom'schen Drüsen vortäuschte.

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Authors and Affiliations

  1. Universitäts-Augenklinik, Kilianstr. 5, D-7800, Freiburg, Germany

    H. Witschel

  2. Department of Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, D.C., USA

    L. E. Zimmerman

Authors
  1. H. Witschel
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  2. L. E. Zimmerman
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The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense

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Witschel, H., Zimmerman, L.E. Malignant mixed tumor of the lacrimal gland. Albrecht von Graefes Arch. Klin. Ophthalmol. 216, 327–337 (1981). https://doi.org/10.1007/BF00455040

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  • DOI: https://doi.org/10.1007/BF00455040

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