Abstract
The beta-blocking agent Nadolol and the beta- and alpha-blocking agent Labetalol were screened for their potential efficacy on intraocular pressure (IOP) in glaucoma. Nadolol 2% and Labetalol 1% in aqueous solution were investigated in a single-dose manner on the basis of a double-masked clinical trial. Only Nadolol reduced IOP significantly which was maximal 4 h after drug application and had a duration of action of at least 6 h and less than 24 h. Blood pressure, pulse rate, and pupil diameter were not significantly affected, and Labetalol did not change either parameter significantly. It is concluded that Nadolol may be of use in glaucoma therapy.
Zusammenfassung
Der Betablocker Nadolol und der Alpha- und Betablocker Labetalol wurden hinsichtlich ihrer möglichen Wirksamkeit auf den Augeninnendruck bei Glaukom untersucht. Nadolol 2% und Labetalol 1% wäßrige Augentropfen wurden bei einmaliger Anwendung im Sinne einer kontrollierten, klinischen Studie untersucht. Nur Nadolol senkte den Augeninnendruck signifikant mit einem Maximum des Effektes 4 h nach Applikation und einer Wirkungsdauer von mindestens 6 h aber weniger als 24 h. Blutdruck, Pulsfrequenz und Pupillendurchmesser waren nicht signifikant verändert. Labetalol zeigte keine Wirkung auf eine der vier Meßgrößen. Es wird geschlossen, daß Nadolol in der Glaukomtherapie von Nutzen sein könnte.
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Krieglstein, G.K., Kontić, D. Nadolol and Labetalol: Comparative efficacy of two beta-blocking agents in glaucoma. Albrecht von Graefes Arch. Klin. Ophthalmol. 216, 313–317 (1981). https://doi.org/10.1007/BF00455038
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DOI: https://doi.org/10.1007/BF00455038