Skip to main content

Advertisement

SpringerLink
Log in

Osteocalcin levels in chronic osteomyelitis

  • Clinical and Experimental Forum
  • Published:
Archives of Orthopaedic and Trauma Surgery Aims and scope Submit manuscript

Abstract

Osteocalcin is a vitamin K-dependent bone protein synthesized by osteoblasts. In generalized bone disorders serum osteocalcin correlates with osteoblast activity. Bone resorption and new bone formation occur in chronic osteomyelitis, dependent on the level of inflammatory activity. In 17 patients with active chronic osteomyelitis undergoing surgery, the serum levels of osteocalcin, alkaline phosphatase and C-reactive protein were measured before and after treatment. The osteocalcin levels were within the normal range preoperatively (10.8 ±11.0 μg/l), in the early postoperative period, and at discharge. It is therefore not a helpful marker in the clinical management of this condition.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Böhm E (1986) Morphologische Grunderscheinungsformen der posttraumatischen Osteomyelitis. In: Böhm E (ed) Chronische posttraumatische Osteomyelitis. (Hefte Unfallheilkd 176) Springer, Berlin Heidelberg New York, pp 13–33

    Google Scholar 

  2. Brown JP, Delmas PD, Malaval L, Edouard C, Chapuy MC, Meunier PJ (1984) Serum bone Gla-protein: a specific marker for bone formation in postmenopausal osteoporosis. Lancet 1:1091–1093

    Google Scholar 

  3. Charhon SA, Delmas PD, Malaval L, Chavassieux PM, Arlot M, Chapuy MC, Meunier PJ (1986) Serum bone gla-protein in renal osteodystrophy: comparison with bone histomorphometry. J Clin Endocrinol Metab 63:892–897

    Google Scholar 

  4. Duncan H, Frost HM, Villanueva AR, Sigler JW (1965) The osteoporosis of rheumatoid arthritis. Arthritis Rheum 8:943–944

    Google Scholar 

  5. Ekenstam EA, Ljunghali S, Hallgren R (1986) Serum osteocalcin in rheumatoid arthritis and other inflammatory arthritides: relation between inflammatory activity and the effect of glucocorticoids and remission inducing drugs. Ann Rheum Dis 45:484–490

    Google Scholar 

  6. Franck H, van Valen F, Keck E, Kruskemper HL (1986) Osteocalcin and bone metabolism in rheumatoid arthritis and osteoarthritis. Z Rheumatol 45:241–246

    Google Scholar 

  7. Franck H, Ittel TH, Tasch O, Herborn G, Rau R (1992) Wechselwirkung von Entzündungsaktivität, anatomischem Stadium und Therapie auf den Serum-Osteocalcin-Spiegel bei Patienten mit chronischer Polyarthritis: In: Ittel TH, Siebert HG, Mattiaß HH (eds) 6. Jahrestagung der Demschen Gesellschaft für Osteologie e. V., Aachen 1991. Aktuelle Aspekte der Osteologie. Springer, Berlin Heidelberg New York, p 452

    Google Scholar 

  8. Gallop PM, Lian JD, Hauschka PV (1980) Carboxylated calcium binding protein and vitamin K. N Engl J Med 302:1460–1466

    Google Scholar 

  9. Gundberg CM, Markowitz ME, Mizruchi M, Rosen JF (1985) Osteocalcin in human serum: a circadian rhythm. J Clin Endocrinol Metab 60:736–739

    Google Scholar 

  10. Lian JB, Gundberg CM (1988) Osteocalcin. Biochemical considerations and clinical applications. Clin Orthop 226:267–291

    Google Scholar 

  11. Malluche HH, Faugere MC, Fanti P, Price PA (1984) Plasma levels of bone Gla-protein reflect bone formation in patients on chronic maintenance dialysis. Kidney Int 26:869–874

    Google Scholar 

  12. Markowitz ME, Gundberg CM, Rosen JF (1987) The circadian rhythm of serum osteocalcin concentrations: effects of 1,25-dihydroxy-vitamin D administration. Calcif Tissue Int 40:179–183

    Google Scholar 

  13. Price PA, Parthemore JG, Deftos LJ (1980) New biochemical marker for bone metabolism. J Clin Invest 66:878–883

    Google Scholar 

  14. Price PA, Lothringer JW, Baukol SA, Reddi AH (1981a) Developmental appearance of the vitamin K-dependent protein of bone during calcification. J Biol Chem 256:3781–3784

    Google Scholar 

  15. Price PA, Williamson MK, Lothringer JW (1981b) Origin of the vitamin K-dependent bone protein found in plasma and its clearance by kidney and bone. J Biol Chem 256:12760–12766

    Google Scholar 

  16. Stracke H, Schatz H (1987) Osteocalcin: ein spezifischer Parameter bei Knochenstoffwechselerkrankungen. Lab Med 11:324–327

    Google Scholar 

  17. Venbrocks RA (1989) Osteocalcin. Ein Indikator des Knochenstoffwechsels. Enke, Stuttgart

    Google Scholar 

  18. Venbrocks R, Münzenberg KJ (1991) Die Wertigkeit serologischer Parameter in der Diagnostik und Therapiekontrolle der Osteoporose. Z Orthop 129:111–117

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Orthopaedic Surgery, Rheinisch-Westfälische Technische Hochschule, Aachen, Germany

    T. Rosendahl, K. D. Heller, R. Weigmann & K. W. Zilkens

  2. Orthopädische Klinik, Klinikum Ingolstadt, Postfach 21 06 62, D-85021, Ingolstadt, Germany

    K. M. Peters

Authors
  1. K. M. Peters
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Rosendahl
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. D. Heller
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Weigmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K. W. Zilkens
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Peters, K.M., Rosendahl, T., Heller, K.D. et al. Osteocalcin levels in chronic osteomyelitis. Arch Orthop Trauma Surg 114, 53–55 (1994). https://doi.org/10.1007/BF00454739

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00454739

Keywords

Search

Navigation