Abstract
The pathogenicity of Cylindrocarpon tonkinense in the cornea was evaluated and compared with that of Fusarium solani in rabbits. F. solani was inoculated into the right eyes of 14 rabbits and C. tonkinense was into the left eyes of same rabbits. The corneal lesions of both eyes were examined carefully by slit lamp every day for three weeks and the severity of infections were compared each other. For histopathologic study, several eyes were enucleated periodically. C. tonkinense has a pathogenicity equally strong as F. solani in this inculum size (104 microconidia per cornea) and produced severe infection in rabbit eyes.
Similar content being viewed by others
References
Booth C: The genus Cylindrocarpon. Mycological papers 104, Commonwealth Mycological Institute Kew, 1966.
Burda CD, Fisher Jr E: The use of cortisone in establishing experimental fungal keratitis in rats. Am J Ophthalmol 48:330–335, 1959.
Editorial: Direct fungal infection of the eye and its prevention. Br J Ophthalmol 60: 605–606, 1976.
Forster RK, Rebell G: The diagnosis and management of keratomycosis. Arch Ophthalmol 93:975–978, 1975.
Forster RK, Rebell G: Animal model of Fusarium solani keratitis. Am J Ophthalmol 79:510–515, 1975.
Francois J, Rijsselaere M: Corticosteroids and ocular mycoses. Ann Ophthalmol 6:207–217, 1974.
Gugnani HC, Talwar RS, Njoku-obi ANV, Kodilinye HC: Mycotic keratitis in Nigeria. Br J Ophthalmol 60:607–613, 1976.
Ishibashi Y: Experimental fungal keratitis due to Fusarium. Improvement of inoculation technique and re-examination of animal model. Acta Soc Ophthalmol Jpn 82:643–651, 1978.
Ishibashi Y: Experimental fungal keratitis due to Fusarium. Studies on animal model and inoculation technique. Shimizu K (ed) XXIII Concilium Ophthalmol Kyoto 1978, Amsterdam-Oxford, Excerpta Medica, Acta pars II, 1978, pp 1705–1708.
Ishibashi Y: Keratomycosis in Japan reported from 1976 to 1980. Acta Soc Ophthalmol Jpn 86:651–656, 1982.
Ishibashi Y, Matsumoto Y: Oral ketoconazole therapy for experiments, Candida albicans keratitis in rabbits. Sabouraudia 22:323–330, 1984.
Ishibashi Y, Matsumoto Y: Intravenous miconazole therapy for experimental keratomycosis in rabbits. Sabouraudia 23:55–61, 1985.
Ishibashi Y, Kaufman HE: The effects of subconjunctival miconazole in the treatment of experimental Candida keratitis in rabbits. Arch Ophthalmol 103:1570–1573, 1985.
Jones BR: Principles in the management of oculomycosis. Am J Ophthalmol 79:719–751, 1975.
Jones DB, Sexton RR, Rebell G: Mycotic keratitis in South Florida. A review of 39 cases. Trans Ophthalmol Soc UK 89:781–797, 1969.
Jones DB, Forster RK, Rebell G: Fusarium solani keratitis treated with Natamycin (Pimaricin). Arch Ophthalmol 88:147–154, 1972.
Laverde S, Moncada LH, Restrepo A, Vera CL: Mycotic keratitis: 5 cases caused by unusual fungi. Sabouraudia 11:119–123, 1973.
Matsumoto T, Masaki J, Okabe T: Cylindrocarpon tonkinense; As a cause of keratomycosis. Trans Br Mycol Soc 72:503–504, 1979.
Polack FM, Kaufman HE, Newmark E: Keratomycosis; Medical and surgical treatment. Arch Ophthalmol 85:410–416, 1971.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ishibashi, Y., Kaufman, H.E., Matsumoto, T. et al. The pathogenicities of Cylindrocarpon tonkinense and Fusarium solani in the rabbit cornea. Mycopathologia 94, 145–152 (1986). https://doi.org/10.1007/BF00454592
Issue Date:
DOI: https://doi.org/10.1007/BF00454592