Summary
In a randomized trial, 55 patients with acute external otitis were treated with either topical framycitin/gramicidin (Sofradex) or oxytetracycline/hydrocortisone (Terracortril) with polymyxin B (TPB) ear-drops for 1 week. Staphylococcus aureus and Pseudomonas pyocyanea were the bacteria most frequently found in the ear canal; 78% of the patients were cured. However, no significant differences in therapy were found when either of the preparations was used. S. aureus seemed to be most resistant to treatment, while P. pyocyanea was less of a therapeutic problem. Additionally, previous episodes of external otitis or other skin diseases did not seem to influence any treatment given.
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References
Brook J (1981) Microbiological studies of the bacterial flora of the external auditory canal in children. Acta Otolaryngol (Stockh) 91:285–287
Densert O, Toremalm G (1972) Pain relief with indomethacin in external otitis. Arch Otolaryngol 95:460–463
Holland JW (1962) Acute otitis externa: etiology, diagnosis and management. J Med Soc New Jersey 59:506–510
Jones EH (1971) Allergy of the external ear. Otolaryngol Clin North Am 4:535–547
Jones EH, McLain PG (1962) Fungal infections of the external ear canal. Southern Med J 55:910–915
McKelvie M, McKelvie P (1966) Some aetiological factors in otitis externa. Br J Dermatol 78:227–231
Morrison AW, Mackay IS (1976) The aetiology of otitis externa — a new concept. J Laryngol Otol 90:495–497
Peterkin GAG (1974) Otitis externa. J Laryngol Oto 88:15–21
Rasmussen PA (1974) Otitis externa and allergic contact dermatitis. Acta Otolaryngol (Stockh) 77:344–347
Senturia BH, Marcus MD, Lucente FE (1980) Diseases of the external ear. An otologicdermatologic manual. Grune and Stratton, New York
Schuknecht HF (1974) Disorders of intoxication. Pathology of the ear. Harvard University Press, Cambridge, Mass, pp 273–290
Stewart EP (1951) Chronic exudative otitis externa. J Laryngol Otol 65:24–32
Wennmo C, Emgård P (1984) Läkartidningen 81:449
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Wadsten, C.J., Bertilsson, C.A., Sieradzki, H. et al. A randomized clinical trial of two topical preparations (framycitin/gramicidin and oxytetracycline/ hydrocortisone with polymyxin B) in the treatment of external otitis. Arch Otorhinolaryngol 242, 135–139 (1985). https://doi.org/10.1007/BF00454412
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DOI: https://doi.org/10.1007/BF00454412