Zusammenfassung
Zur Erfassung altersbedingter Veränderungen des am weitesten peripher gelegenen neuralen Anteils der Hörbahn wurde das Summenaktionspotential des Hörnerven beim Meerschweinchen untersucht. Neben einem ausgeprägten Schwellenverlust, fand sich eine signifikant geringere Amplitude bei alten Versuchstieren. Die Latenz des Summenaktionspotentials dagegen zeigte sich unverändert. Dies deutet unter Berücksichtigung der sich bei jungen und alten Meerschweinchen entsprechenden Amplitudenzunahme im untersuchten Intensitätsbereich darauf hin, daß die noch erregten Neurone des N. acusticus keine Einbußen ihrer Funktionsfähigkeit im Alter erfahren.
Summary
As a measure of age-related changes in the most peripheral neural part of the auditory pathway, the compound action potential of the guinea pig was analyzed. In addition to a marked threshold elevation, there was a significantly lower potential amplitude in old animals. By contrast, the latency of the compound action potential was unchanged. In view of the fact that the relative amplitude increase in the intensity range tested was the same in old as in young animals, the implication is that the auditory-nerve neurons that are still excited do not exhibit functional deterioration with aging.
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With the support of the Deutsche Forschungsgemeinschaft (DFG)
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Dum, N. Age-dependent changes of the compound action potential in the guinea pig. Arch Otorhinolaryngol 238, 179–187 (1983). https://doi.org/10.1007/BF00454311
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DOI: https://doi.org/10.1007/BF00454311