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A possible method to study transient effects of ototoxic agents on the vestibular system

Eine Methode zur Untersuchung der vorübergehenden Wirkung ototoxischer Substanzen auf das vestibuläre System

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Zusammenfassung

Darstellung einer Methode zur Untersuchung des Einflusses von Anoxie und ototoxischen Substanzen auf das vestibuläre System. Nach Fensterung des lateralen Bogenganges bei der Taube konnte das Aktionspotential des N. vestibularis während akustischer Reizung registriert werden bei gleichzeitiger Ableitung des Aktionspotentials des N. cochlearis. Der Einfluß ototoxischer Substanzen und von Anoxie auf die Amplituden dieser Aktionspotentiale wurden untersucht.

Summary

A method is described in which the direct influence of anoxia and ototoxic agents on the vestibular system can be studied. After fenestration of the lateral semicircular canal in pigeons, a vestibular whole nerve action potential (VAP) could be recorded during acoustic stimulation. The cochlear whole nerve action potential (CAP) was recorded simultaneously. The influence of ototoxic agents and anoxia upon the amplitude of these action potentials was studied.

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Authors and Affiliations

  1. Institute of Audiology, University Hospital, Postbox 30 001, 9700, RB Groningen, The Netherlands

    H. P. Wit

  2. Department of Otorhinolaryngology, University Hospital, Groningen, The Netherlands

    J. D. Bleeker

Authors
  1. H. P. Wit
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  2. J. D. Bleeker
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Wit, H.P., Bleeker, J.D. A possible method to study transient effects of ototoxic agents on the vestibular system. Arch Otorhinolaryngol 238, 175–178 (1983). https://doi.org/10.1007/BF00454310

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  • DOI: https://doi.org/10.1007/BF00454310

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