Zusammenfassung
Verfasser konnten zum ersten Mal α-1 adrenergische, β-adrenergische und muskarin-cholinergische Rezeptoren in der menschlichen Nasenschleimhaut bei Patienten mit nasaler Allergie oder Sinusitis nachweisen. Muskarin-Rezeptoren fanden sich bei nasaler Allergie vermehrt, α-1 und β-Rezeptoren waren dagegen vermindert. Bei Sinusitis war dies nicht der Fall. Nach Ansicht der Verfasser spielen Störungen der autonomen Nervenrezeptoren eine wichtige Rolle bei der Pathologie der nasalen Allergie.
Summary
We have demonstrated for the first time α-1 adrenergic, β-adrenergic, and muscarinic cholinergic receptors in human nasal mucosa obtained from patients with nasal allergy or sinusitis. Using the radioligand 3H-prazosin, 3H-dihydroalprenolol (3H-DHA) and 3H-quinaclidinyl benzilate (3H-QNB), we determined the receptor densities (Bmax) and affinities (KD) of α-1, β, and muscarinic receptors. There was an increased number of muscarinic receptors and a decreased number of α-1, β receptors in patients with nasal allergy but not in those with sinusitis. Binding affinites (KD) of α-1, β, and muscarinic receptors were unchanged in all patients with nasal allergy and sinusitis. Disorders of the autonomic nerve receptors appear to play a definite role in pathology of nasal allergy.
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Supported by grants from the Ministry of Education, Science and Culture and the Ministry of Health and Welfare, Japan
This paper represents a part of the dissertation submitted by T.I. to Kansai Medical University, for the requirement of Doctor of Philosophy
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Ishibe, T., Yamashita, T., Kumazawa, T. et al. Adrenergic and cholinergic receptors in human nasal mucosa in cases of nasal allergy. Arch Otorhinolaryngol 238, 167–173 (1983). https://doi.org/10.1007/BF00454309
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DOI: https://doi.org/10.1007/BF00454309