Zusammenfassung
Bericht über einen Hypophysentumor bei einem 43jährigen Mann. Der Tumor, der nur TSH produzierte, wurde auf transsphenoidalem Wege entfernt. Die morphologische Untersuchung zeigte, daß der Tumor nur aus einer Zellart bestand. Die Zellkultur bestätigte die ausschließliche Sekretion von TSH.
Summary
A pituitary tumor secreting thyroid-stimulating hormone (TSH) only was diagnosed in a 43-year-old man who originally showed signs and symptoms of thyreotoxicosis which recurred twice. Despite normal serum levels of T3 and T4, increased levels of TSH were diagnosed. The pituitary tumor was operated by the transsphenoidal approach. Morphological analysis of tumor tissue showed cellular pleomorphism and regressive changes. Nuclear DNA analysis showed that the tumor had only one cell line and an aneuploid DNA pattern. In vitro culture of tumor tissue confirmed that the tumor secreted TSH only.
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References
Duello TM, Halmi NS (1977) Pituitary adenoma producing thyrotropin and prolactin. An immunocytochemical and electron microscopic study. Virchows Arch [Pathol Anat] 376: 5–265
Tolis G, Bird C, Bertrand G, McKenzie JM, Ezzin C (1978) Pituitary hyperthyroidism — case report and review of the literature. Am J Med 64: 177–181
Leong ASY, Chawla JC, Teh E-C (1976) Pituitary thyrotropic tumour secondary to longstanding primary hypothyroidism. Pathol Eur 11: 49–55
Filetti S, Rapoport B, Aron DC, Greenspan FC, Wilson CB, Fraser N (1982) TSH and TSH-subunit production by human thyrotropic tumour cells in monolayer culture. Acta Endocrinol 99: 224–231
Cravito H, Fukaya T, Zimmerman EA, Kleinberg BL, Flamm ES (1981) Immunohistochemical and electron microscopic studies of functional and non-functional pituitary adenomas including one TSH secreting tumour in thyrotoxic patient. Acta Neuropathol (Berl) 53: 281–292
Benoid T, Pearson-Murphy BE, Robert F, Marcovitz S, Hardy J, Tsoukas G, Gardiner RJ (1980) Hyperthyroidism due to a pituitary TSH secreting tumour with amenorrhoea and galactorrhoea. Clin Endocrinol (Oxf) 12: 11–19
Anniko M, Lundquist P-G, Ritzén M, Samuelsson K, Tribukait B, Wersäll J (1982) Pituitary tumour producing only thyrotropin. A case report. Adv Otorhinolaryngol 44: 134–141
Anniko M, Holm L-E, Tribukait B, Werner S (1981) DNA characteristics of human pituitary tumours. Acta Otolaryngol (Stockh) (Suppl) 379: 5–11
Anniko M, Werner S, Wersäll J (1980) Growth hormone and prolactin production in human pituitary tumours in organ culture. Acta Otolaryngol (Stockh) 90: 143–151
Faglia G, Ferrari C, Neri V, Beck-Peccoz P, Ambrosi B, Valentini F (1972) High plasma thyrotropin levels in two patients with pituitary tumour. Acta Endocrinol (Kbh) 69: 649–658
Meinders AE, Willekens FLA, Barends CAE, Seevinck J, Neiuwenhuijzen-Kruseman AC (1981) Acromegaly and thyrotoxicosis induced by a GH- and TSH-producing pituitary tumour which also contained prolactin. Neth J Med 24: 136–144
Koide Y, Kugai N, Kimura S, Fujita T, Kameya T, Azukizawa M, Ogata E, Tomono Y, Yamashita K (1982) A case of pituitary adenoma with possible simultaneous secretion of thyrotropin and follicle-stimulating hormone. J Clin Endocrinol Metab 54: 397–403
Saeger W, Lüdecke DK (1982) Pituitary adenomas with hyperfunction of TSH. Frequency, histological classification, immunocytochemistry and ultrastructure. Virchows Arch [Pathol Anat] 394: 255–267
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Supported by grants from the Ragnar and Torsten Söderberg Foundation and The Cancer Society in Stockholm
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Anniko, M., Tribukait, B., Werner, S. et al. TSH-secreting pituitary tumor. Arch Otorhinolaryngol 238, 135–142 (1983). https://doi.org/10.1007/BF00454305
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DOI: https://doi.org/10.1007/BF00454305